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NCT Number: NCT07765095

Pericapsular Nerve Group (PENG) Block on Postoperative Pain Management After Acetabular Fracture Fixation

The goal of this clinical trial is to find out whether a Pericapsular Nerve Group (PENG) block, a type of nerve block used to control pain, can reduce pain after surgery in adults with an acetabular (hip socket) fracture who are undergoing surgical repair. The study will also evaluate the safety of the PENG block.

The main questions this study aims to answer are:

Does a PENG block reduce pain after surgery? Does a PENG block reduce the need for opioid pain medications after surgery? Are there any side effects or complications related to the PENG block? Researchers will compare patients who receive a PENG block with patients who do not receive a PENG block to determine whether the block improves pain control after surgery.

Participants will:

Be randomly assigned to receive either a PENG block or no PENG block before surgery while under general anesthesia.

Undergo surgery to repair their acetabular fracture. Receive the same standard pain medications after surgery. Be asked to rate their pain at several time points after surgery using a standard pain scale.

Have their use of pain medications, recovery, and any side effects recorded during their hospital stay and follow-up.

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Key information

Conditions

Acetabular Fractures Agnosia Nervous System Diseases Neurobehavioral Manifestations Neurologic Manifestations Pathological Conditions, Signs and Symptoms Perceptual Disorders Signs and Symptoms

Age range

18 year and older

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Puerto Rico Medical Center

San Juan, 00935, Puerto Rico

Location status: Recruiting

Location contact

Luis Lojo Sojo, MD

PRINCIPAL_INVESTIGATOR

Luis Lojo-Sojo, MD

CONTACT

[email protected]

787773535

Norberto J Torres Lugo, MD

SUB_INVESTIGATOR

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Patient age 18 years or older
  • Acetabular Fracture amenable to surgery through the Kocher-Langenbeck approach
  • Full weight-bearing capacity prior to the trauma
  • Providing written informed consent

Exclusion criteria

  • Age less than 18 years old
  • Fracture pattern not amenable to surgery through Kocher-Langenbeck approach
  • Lower extremity fracture ipsilateral to the acetabular fracture
  • Any traumatic injury that requires surgical management by other surgical specialty
  • Bilateral Acetabular Fractures
  • Limited weight bearing capacity prior to the trauma
  • Procedure performed under any anesthesia other than GETA
  • Chronic opioid use
  • History of Substance Abuse
  • Allergies or history of adverse reactions to any of the drugs used in the
  • Mental Disability
  • History of Psychiatric disorders

Treatment and study plan

pericapsular nerve group (PENG) block

Procedure

PENG Block is a regional block technique well documented in the literature for certain orthopedic injuries and interventions. However, the efficacy of this intervention on acetabular fracture fixation has not been well studied or addressed in previous literature.

Primary outcomes

  1. Numeric Pain Rating Scale (NPRS)

    Time frame: From surgery to 48 hours after surgery (12 hour Intervals)

    The NPRS is an 11-point scale scored from 0-10, with " 0 " representing no pain and "10" being the most intense pain experienced. Patients verbally select a value that is most in line with the intensity of pain that they have experienced at each time point under evaluation.

Secondary outcomes

  1. Morphine Miligram Equivalent (MME)

    Time frame: From surgery to 48 hours after surgery (12 hour Intervals)

    MME is the total amount of an opioid drug converted to an equivalent strength of oral morphine. This measure is used to track the consumption of opioids in a standardized, uniform way.

  2. Time to first opioid dose

    Time frame: From surgery to 48 hours after surgery (Will quantify from surgery to time of administration)

    Will measure in minutes the time that patient spent without consuming opioids before requesting their first rescue therapy (opioid) dose.

  3. Postoperative Complications

    Time frame: From surgery to 48 hours after surgery

    Inpatient complications are unforeseen medical issues that arise during a hospital stay, potentially extending recovery time or requiring additional treatment.

Sponsors and collaborators

Lead sponsor

University of Puerto Rico

Other

Registry information

Official study title

Efficacy of Pericapsular Nerve Group (PENG) Block on Postoperative Pain Management After Acetabular Fracture Fixation: A Randomized Controlled Trial

Important dates

Study start
2025
Primary completion
2027
Study completion
2027
First posted
Aug 14, 2026
Registry last updated
Aug 14, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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