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NCT Number: NCT07764809

Driving Time and Facial Skin Hydration Asymmetry in Florida Drivers

his observational study examines whether time spent driving is associated with differences in skin hydration between the left and right cheeks in female drivers residing in Florida. In left-hand-drive vehicles, the driver's left cheek is chronically exposed to ultraviolet A (UVA) radiation through the unshaded side window during every daytime driving episode. A prior study by IAS Skin Care (NCT07564869, n=30) found that the left cheek was less hydrated than the right cheek in 60% of participants, suggesting a possible effect of driving-related UVA exposure on facial skin hydration asymmetry.

Eighty female drivers aged 25-65 years residing in Florida will be enrolled. At a single visit, skin hydration will be measured at three facial zones (left cheek, right cheek, and forehead as a symmetrical control zone) using the BT-Analyze bioimpedance device. Participants will complete a structured questionnaire on driving habits, sun protection practices, and skin history. The primary outcome is the Hydration Asymmetry Index (HAI = right cheek minus left cheek BT-Analyze score). Associations between driving time, cumulative driving exposure, window tinting, sunscreen use, and HAI will be examined using Spearman correlation, Mann-Whitney U tests, and multiple linear regression.

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Key information

Conditions

Skin Diseases Facial Asymmetry Pathological Conditions, Anatomical Pathological Conditions, Signs and Symptoms Photoaging Skin Hydration Skin and Connective Tissue Diseases

Age range

25 year–65 year

Sex eligibility

Female

Study type

Observational

Primary location

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Female sex, aged 25 to 65 years (inclusive)
  • Valid driver's license and active driving for a minimum of 3 years
  • Driving frequency of at least 3 days per week on average
  • Florida residency for a minimum of 2 years prior to enrollment
  • Ability to provide written informed consent in English or Russian

Exclusion criteria

  • Window tinting on the driver-side window of the participant's primary vehicle
  • Regular sunscreen application specifically to the left side of the face before driving (more than half of driving occasions in the past month)
  • Active skin disease on the face at time of assessment
  • Injectable cosmetic procedures (Botox or fillers) in the past 6 months
  • Laser resurfacing or chemical peel in the past 3 months
  • Inability to refrain from facial cosmetics for at least 2 hours prior to the visit

Treatment and study plan

BT-Analyze bioimpedance skin hydration measurement

Other

Non-invasive skin hydration measurement at three facial zones (right cheek, left cheek, forehead) using the BT-Analyze bioimpedance device. Three measurements per zone. Single visit.

Primary outcomes

  1. Hydration Asymmetry Index (HAI)

    Time frame: Single visit (Day 1)

    Difference in mean BT-Analyze bioimpedance scores between the right and left cheeks (HAI = right cheek mean minus left cheek mean). A positive value indicates lower hydration on the left cheek relative to the right.

Secondary outcomes

  1. Correlation between cumulative driving exposure and HAI

    Time frame: Single visit (Day 1)

    Spearman correlation between cumulative driving exposure index (years of driving × hours per week) and the Hydration Asymmetry Index.

  2. HAI by window tinting status

    Time frame: Single visit (Day 1)

    Comparison of Hydration Asymmetry Index between participants with tinted versus untinted driver-side windows, assessed by Mann-Whitney U test.

  3. HAI by sunscreen application habit

    Time frame: Single visit (Day 1)

    Comparison of Hydration Asymmetry Index between participants who regularly apply sunscreen to the left side of the face before driving and those who do not, assessed by Mann-Whitney U test.

  4. Forehead hydration as symmetry reference

    Time frame: Single visit (Day 1)

    Forehead BT-Analyze score used as a bilateral symmetry reference zone to confirm that observed cheek asymmetry is directional and not attributable to general hydration differences.

Study contacts

Contact information is provided by the study sponsor or research team.

Olga IAS, M.Sc

CONTACT

[email protected]

689-249-26-77

Sponsors and collaborators

Lead sponsor

IAS Skin Care

Industry

Registry information

Official study title

Driving Time and Left-Cheek Skin Hydration Asymmetry in Florida Residents: An Observational Study on Cumulative UVA Exposure Through Vehicle Side Windows

Acronym: DCHA-FL-25-65

Important dates

Study start
2026
Primary completion
2027
Study completion
2027
First posted
Aug 14, 2026
Registry last updated
Aug 14, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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