Early Implementation of Sacral Neuromodulation in Patients With Low Anterior Resection Syndrome.

Inclusion criteria

• Adult patients (18 years of age or older) who are capable of signing the appropriate informed consent form.
• Patients who have undergone an anterior rectal resection for rectal cancer, with an anastomosis, whether or not they have received neoadjuvant therapy, and who have bowel function, either via a direct anastomosis or following reconstruction of a lateral ileostomy.
• Patients who experience more than 6 episodes of urgency and/or incontinence in the following two weeks after the screening visit, as recorded in a daily bowel diary.
• Patients with a LARS score >21 points (major or minor LARS).
• Patients who report at least one symptom and one consequence as defined by the international definition.

Exclusion criteria

• Metastatic disease at the time of surgery.
• Need for adjuvant chemotherapy at the time of assessment.
• Active chemotherapy.
• Patients with an ileostomy.
• Intellectual or language-related difficulty in answering the questionnaires.
• Refusal to participate in the study or failure to commit to follow-up visits.
• Patients with contraindications for sacral neuromodulation implantation (those with pacemakers, active infections, or allergies to prosthetic materials).
• Patients with active inflammatory bowel disease at the time of surgery.
• Patients who have undergone other intestinal resections in addition to rectal resection.