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OpenTrials
Completed

NCT Number: NCT07761585

Effect of Preoperative Dexamethasone in Preventing Spinal Hypotension In Patients Undergoing Elective Caesarian Section

The goal of this clinical trial is to learn whether giving a single dose of intravenous dexamethasone before spinal anesthesia can help prevent low blood pressure (spinal hypotension) in pregnant women undergoing elective cesarean section. Low blood pressure after spinal anesthesia is common and may cause nausea, vomiting, dizziness, and reduced blood flow to the baby. If dexamethasone works, it may help maintain stable blood pressure during surgery, reduce the need for medicines used to treat low blood pressure, and improve the safety and comfort of both the mother and baby.

The main questions it aims to answer are:

* Does preoperative intravenous dexamethasone reduce the occurrence of spinal hypotension after spinal anesthesia? * Does dexamethasone reduce the amount of vasopressor medicine needed to treat low blood pressure during surgery?

Researchers will compare 8 mg intravenous dexamethasone with normal saline (placebo) to determine whether dexamethasone is more effective in preventing spinal hypotension during elective cesarean section.

Participants will:

* Receive either intravenous dexamethasone or a placebo before spinal anesthesia. * Undergo elective cesarean section under spinal anesthesia. * Have their blood pressure monitored during surgery. * Receive standard treatment if their blood pressure becomes too low. * Have their blood pressure measurements and the need for blood pressure-raising medicines recorded to compare the effects of the two treatments.

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Key information

Conditions

Age range

18 year and older

Sex eligibility

Female

Study type

Interventional

Phase

Not applicable

Primary location

Liaquat National Hospital

Karachi, Pakistan

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Pregnant females Consenting No contraindications

Exclusion criteria

  • Non consenting

Treatment and study plan

Dexamethasone

Drug

Dexamethasone

Primary outcomes

  1. Spinal hypotension

    Time frame: From spinal anesthesia until delivery of the baby (approximately 20 minutes) at 5 minutes interval for a period of 6 months.

    The incidence of spinal hypotension, defined as a decrease in systolic blood pressure (SBP) greater than 20% of the baseline value or an absolute SBP <90 mmHg after spinal anesthesia, will be compared between the dexamethasone and placebo groups. Blood pressure will be measured every 5 minutes until delivery of the baby.

Secondary outcomes

  1. Vasopressor Requirement

    Time frame: From spinal anesthesia until delivery of the baby (approximately 20 minutes ) at 5 minutes interval for a period of 6 months

    Total dose and frequency of vasopressor administration required to treat spinal hypotension following spinal anesthesia will be compared between the dexamethasone and placebo groups.

Sponsors and collaborators

Lead sponsor

Liaquat National Hospital & Medical College

Other

Registry information

Important dates

Study start
2026
Primary completion
2026
Study completion
2026
First posted
Aug 12, 2026
Registry last updated
Aug 12, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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