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NCT Number: NCT07760727

High-Flow Nasal Oxygyen Therapy During Sedated Endobronchial Ultrasound-Guided Transbronchial Needle Aspiration(EBUS-TBNA)

This study aims to evaluate the effects of high-flow nasal oxygen therapy on respiratory complications, blood gas parameters, and post-procedural recovery in patients undergoing sedated endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA). Participants will be assigned to receive either high-flow nasal oxygen therapy or conventional oxygen therapy during the procedure. The incidence of respiratory complications, blood gas changes, and recovery outcomes will be compared between the two groups.

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Key information

Conditions

High Flow Oxygen Therapy Blood Gas Analysis ENDOBRONCHIAL ULTRASOUND - TRANSBRONCHIAL NEEDLE ASPIRATION Sedation Sedation Complication

Age range

18 year and older

Sex eligibility

All sexes

Study type

Observational

Primary location

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

Age ≥18 years. Scheduled to undergo sedated EBUS-TBNA. Ability to provide written informed consent. ASA physical status I-III.

Exclusion criteria

  • Age <18 years.
  • Pregnancy.
  • Requirement for endotracheal intubation or general anesthesia.
  • Severe hemodynamic instability.
  • Refusal to participate in the study.
  • Contraindication to high-flow nasal oxygen therapy.

Treatment and study plan

High-Flow Nasal Oxygen Therapy

Device

High-flow nasal oxygen therapy administered during sedated EBUS-TBNA procedures to provide enhanced oxygenation and respiratory support.

Conventional Oxygen Therapy

Device

Conventional oxygen therapy administered during sedated EBUS-TBNA procedures using standard oxygen delivery methods

Primary outcomes

  1. Respiratory Complications

    Time frame: During the procedure

    Incidence of respiratory complications during sedated EBUS-TBNA, including hypoxemia, oxygen desaturation, apnea, airway obstruction, and the need for airway interventions.

Secondary outcomes

  1. Oxygen partial pressure (PaO2)

    Time frame: Baseline and within 15 minutes after completion of the endobronchial Ultrasound-Transbronchial Needle Aspiration (EBUS-TBNA) procedure

    Changes in venous oxygen partial pressure(PaO2) measured at baseline and after sedated EBUS-TBNA

  2. Carbon dioxide partial pressure (PvCO2)

    Time frame: Baseline and within 15 minutes after completion of the EBUS-TBNA

    Changes in venous carbon dioxide partial pressure (PvCO2) measured at baseline and within 15 minutes after completion of sedated EBUS-TBNA.

  3. Venous pH

    Time frame: Baseline and within 15 minutes after completion of the EBUS-TBNA procedure.

    Changes in venous pH measured at baseline and within 15 minutes after completion of sedated EBUS-TBNA

  4. Venous Oxygen Saturation (SvO2)

    Time frame: Baseline and within 15 minutes after completion of the EBUS-TBNA procedure.

    Changes in venous oxygen saturation (SvO2) measured at baseline and within 15 minutes after completion of sedated EBUS-TBNA.

  5. Recovry Time

    Time frame: Up to 2 hours post-procedure

    Time from completion of sedated EBUS-TBNA until achievement of a Modified ALdrete Recovery Score ≥9.

Study contacts

Contact information is provided by the study sponsor or research team.

Güldeniz Argun, Prof

CONTACT

[email protected]

05336230405

ÖZLEM KAPUSUZ KÖRDUMAN, MD

CONTACT

[email protected]

+905058002027

Sponsors and collaborators

Lead sponsor

Dr Abdurrahman Yurtaslan Ankara Oncology Training and Research Hospital

Other

Registry information

Official study title

The Effects of High-Flow Nasal Oxygen Therapy on Respiratory Complications and Post-Procedural Recovery Time in Patients Undergoing Sedated EBUS-TBNA

Important dates

Study start
2026
Primary completion
2026
Study completion
2026
First posted
Aug 12, 2026
Registry last updated
Aug 12, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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