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NCT Number: NCT07760545

Reliability In Neurocognitive Telemedicine Screening (RING)

Perioperative neurocognitive disorders are common after surgery and pre-existing cognitive impairment is an important risk factor. Current guidelines recommend identifying cognitive impairment before surgery; however, screening remains inconsistent, particularly when preoperative assessments are performed remotely.

This prospective observational diagnostic validation study aims to determine whether a modified Mini-Cog cognitive screening tool administered by telephone can reliably identify cognitive impairment in patients aged 65 years and older undergoing preoperative assessment. Telephone-based modified Mini-Cog results will be compared with standard in-person Mini-Cog assessments to evaluate agreement and feasibility. This study may improve access to preoperative cognitive screening and support optimization of surgical care for older adults.

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Key information

Age range

65 year and older

Sex eligibility

All sexes

Study type

Observational

Primary location

Vancouver General Hospital

Vancouver, British Columbia, BC V5Z 1M9, Canada

Location status: Recruiting

Location contact

Donald Young, MD

PRINCIPAL_INVESTIGATOR

Shirley Lim, BSN, BS-HRIM

CONTACT

800-604-875-4111 ext. 66378

Stewart Brown, MD

CONTACT

[email protected]

Stewart Brown, MD

SUB_INVESTIGATOR

About this study

Perioperative neurocognitive disorders (PND) are common and associated with significant morbidity and economic costs. One of the dominant risk factors for PND is pre-existing cognitive impairment (CI). The importance of detecting CI pre-operatively to facilitate patient selection for optimisation pathways and informed risk assessments is stressed in recent joint guidelines by the American College of Surgeons and the American Geriatrics Society.

Despite these recommendations, screening for pre-operative CI is inconsistently performed. One systematic barrier to CI screening is telemedicine, the use of which has recently seen an inflection point partly precipitated by the Coronavirus pandemic. Telemedicine enables the delivery of tertiary level patient-centred care over expanding geographical catchments, and is likely here to stay.

To date, no brief CI screening tool has been validated for perioperative use via telemedicine.

The Mini-Cog is a brief CI screening tool that is uniquely familiar to perioperative healthcare providers. It is validated in preoperative patients and performs favourably compared to other screening tools in the detection of CI. A Mini-Cog result consistent with CI is strongly associated with postoperative delirium, and is widely used as a trigger for geriatric optimization referral.

Validation of the Mini-Cog delivered via telemedicine is an important step towards improving patient access to CI screening.

Although video pre-operative assessments have been shown to promote high levels of patient and anesthesiologist satisfaction6, it is our local experience that video call technology is less frequently available to older patients, can pose operational challenges for either participant, and reduces workflow flexibility.

Clock Drawing Test (CDT) is an integral part of the Mini-Cog, testing multiple domains of executive function and motor skills, and functioning as a 'distractor' between the registration and recall of three items.

A modified Mini-Cog has been used with illiterate patients unable to use an analogue clock. The CDT was replaced with a serial subtraction task (SST) as an alternate distractor. One study found the modified Mini-Cog correlates with a proxy-rated CI screening tool similarly to the standard Mini-Cog.

Whilst it not feasible to perform a Mini-Cog assessment during a telephone interview, the modified Mini-Cog is an attractive alternative. We therefore aim to validate the modified Mini-Cog assessment for use over the telephone.

Our study involves comparing the validated Mini-Cog with the modified Mini-Cog. Patients awaiting surgery performed the Modified-Mini-Cog with telemedicine and on a later date subsequently performed the validated standard Mini-Cog. We plan to analyse the concordance of the results.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Patients with age >65 at time of listing for pre-operative assessment.
  • Patients with a conversational understanding of English language.
  • Patients scheduled for in-person consult with an anaesthesiologist.
  • Patients awaiting surgery at Vancouver General Hospital or University of British Columbia Hospital.

Exclusion criteria

  • Patients with known cognitive impairment.

Treatment and study plan

Modified Mini-Cog Telephone Assessment

Diagnostic Test

A modified Mini-Cog cognitive screening assessment administered by telephone to evaluate its reliability and concordance with standard in-person Mini-Cog assessment in older adults undergoing preoperative assessment.

Primary outcomes

  1. Concordance between telephone-administered modified Mini-Cog and standard in-person Mini-Cog assessment

    Time frame: Within 1-2 weeks of telephone assessment

    Agreement between modified Mini-Cog scores obtained by telephone and standard in-person Mini-Cog scores in identifying cognitive impairment using the established Mini-Cog cutoff score.

Secondary outcomes

  1. Sensitivity and specificity of telephone modified Mini-Cog

    Time frame: Within 1-2 weeks of telephone assessment

    Sensitivity and specificity of the telephone-administered modified Mini-Cog for detection of cognitive impairment compared with the in-person Mini-Cog assessment.

  2. Completion time of modified Mini-Cog assessment

    Time frame: During each assessment

    Time required to complete the telephone and in-person Mini-Cog assessments.

  3. Feasibility of telephone-based cognitive screening

    Time frame: During telephone assessment

    Proportion of participants able to complete the telephone-administered modified Mini-Cog assessment.

Study contacts

Contact information is provided by the study sponsor or research team.

Donald Young, MD

CONTACT

[email protected]

800-604-875-4304 ext. 54304

Shirley Lim, BSN, BS-HRIM

CONTACT

[email protected]

604-875-4111 ext. 66378

Sponsors and collaborators

Lead sponsor

University of British Columbia

Other

Collaborators

  • Vancouver General Hospital

Registry information

Important dates

Study start
2023
Primary completion
2026
Study completion
2027
First posted
Aug 12, 2026
Registry last updated
Aug 12, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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