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OpenTrials
Completed

NCT Number: NCT07760220

Hip Thrust Versus Back Squat Training in Untrained Adults

This study compared the effects of two lower-body resistance training exercises - the barbell back squat and the barbell hip thrust - on muscle growth and strength in untrained young adults. Thirty-four participants were randomly assigned to train using either the back squat or the hip thrust, two times per week for nine weeks. Muscle size (via MRI) and strength (via weightlifting tests) were measured before and after training to determine whether one exercise produced greater improvements than the other, particularly in the gluteal muscles. Muscle activity during the first training session was also measured using surface electromyography (sEMG) to see whether early muscle activation could predict later muscle growth.

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Key information

Age range

18 year–30 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

School of Kinesiology

Auburn, Alabama, 36849-5419, United States

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Age 18-30 years
  • Body mass index (BMI) less than 30 kg/m²
  • Minimal resistance training experience, defined as averaging ≤1 day per week of resistance training over the preceding 5 years
  • Willing and able to provide written informed consent.

Exclusion criteria

  • Participation in structured endurance training (e.g., running or cycling) more than 2 days per week over the past 6 months
  • Known overt cardiovascular or metabolic disease
  • Use of supplemental creatine and/or hormone-altering agents (e.g., testosterone boosters, growth hormone boosters) within the past 2 months
  • Any medical condition that would contraindicate participation in an exercise program
  • Any condition precluding MRI scanning (e.g., medically implanted devices)

Treatment and study plan

Resistance training

Behavioral

Participants performed training twice per week (non-consecutive days) for 9 weeks, totaling 15-17 supervised sessions. Training volume progressed weekly: 3 sets in week 1, 4 sets in week 2, 5 sets in weeks 3-6, and 6 sets in weeks 7-9, matching the set-volume scheme used in the hip thrust group. Each set consisted of 8-12 repetitions performed to volitional muscular failure (defined as the inability to complete another repetition with proper form); load was adjusted as needed to keep repetitions within this range. Repetitions were performed with a controlled tempo (~1-second concentric, ~2-second eccentric). All training sessions were supervised by study personnel. Participants were instructed to refrain from any other lower-body resistance training for the duration of the study.

Primary outcomes

  1. Hypertrophy

    Time frame: Baseline and 9 weeks

    Cross-sectional area of the upper, middle, and lower gluteus maximus was measured via magnetic resonance imaging (MRI) at baseline and following the 9-week training intervention. T1-weighted transverse images were obtained using a 3T MRI scanner, and muscle borders were manually traced using ImageJ software by a single investigator blinded to group allocation. Bilateral (left + right) mCSA values were summed at each of three standardized anatomical sites (upper, middle, and lower gluteus maximus) to assess site-specific hypertrophic response to training.

Secondary outcomes

  1. 3RM strength testing

    Time frame: Baseline and 9 weeks

    Dynamic lower-body strength was assessed via 3-repetition maximum (3RM) testing for the barbell hip thrust, barbell back squat, and barbell deadlift at baseline and following the 9-week training intervention

  2. One-bout EMG gluteal maximus recordings

    Time frame: Single training session within the first week of the intervention.

    Surface electromyography (sEMG) was used to assess muscle excitation of the right upper, middle, and lower gluteus maximus and the right gluteus medius during a single 10-repetition-maximum (10RM) set of both the barbell back squat and barbell hip thrust exercises, performed during participants' first training session. Wireless sEMG electrodes were placed at standardized anatomical sites, and signals were sampled at 1000 Hz, rectified, filtered, and smoothed before being normalized to each participant's maximum voluntary isometric contraction (MVIC) for the corresponding muscle. Mean and peak sEMG amplitudes were calculated for each muscle site during each exercise and compared between the back squat and hip thrust conditions.

Sponsors and collaborators

Lead sponsor

Auburn University

Other

Registry information

Official study title

Hip Thrust and Back Squat Training Elicit Similar Gluteus Muscle Hypertrophy and Transfer Similarly to the Deadlift

Acronym: HTS

Important dates

Study start
2023
Primary completion
2023
Study completion
2024
First posted
Aug 12, 2026
Registry last updated
Aug 12, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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