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OpenTrials
Completed

NCT Number: NCT07758556

Comparison of Alignment Speed, Patient Discomfort and Root Resorption Between Two Different Sequences of Archwires

In this Clinical trial we aim to compare alignment speed, patient discomfort and root resorption between two different sequences of NiTi archwires

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Key information

Age range

12 year–35 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

FUI, Islamabad, Punjab Province, Pakistan

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About this study

This study will establish and evaluate a set of alignment wires that is efficient in terms of reduced number of patient's visits, yet periodontally safe and acceptable in terms of patient discomfort.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

Age range 12-35 years.

  • Both male and female patients.
  • Medically-fit patients with no medical condition associated with root resorption risk.
  • No previous history of orthodontic treatment.
  • Patients requiring complete upper and lower orthodontic treatment with fixed appliance.
  • Angle class I, II, and III malocclusion with crowding in both maxillary and mandibular anterior dentition.
  • Healthy permanent dentition with adequate oral hygiene and no periodontal diseases; before the start of orthodontic treatment.

Exclusion criteria

Cleft lip & palate patients

  • Syndromic patients
  • Patients with bone pathologies
  • Habits such as smoking
  • Patients with parafunctional habits or history of pre-existing root resorption
  • Patients taking drugs which inhibit or accelerate tooth movement
  • Tooth or teeth with periapical infection.
  • Patients with pain from any other medical or dental condition that may have affected their reported discomfort scores were excluded
  • Endodontically treated mandibular or maxillary anterior teeth
  • Presence of blocked-out tooth that did not allow for placement of the bracket or full AW engagement at the initial bonding.

Treatment and study plan

Archwire

Device

NiTi Archwires will be used for tooth alignment

Primary outcomes

  1. Speed of alignment

    Time frame: 6 months

    Speed of alignment will be calculated in terms of number of visits and measured by Littles irregularity Index in millimeters

Secondary outcomes

  1. Patient discomfort

    Time frame: 6 months

    Will be measured as scoring on pain proforma on Visual analogue scale

Other outcomes

  1. Root resorption

    Time frame: 6 months

    Will be measured on periapical radiographs before and after alignment

Sponsors and collaborators

Lead sponsor

Foundation University Islamabad

Other

Registry information

Important dates

Study start
2024
Primary completion
2025
Study completion
2025
First posted
Aug 11, 2026
Registry last updated
Aug 13, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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