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NCT Number: NCT07757971

2D:4D Ratio in Relation to Anxiety and Stress Among Anesthesiology Residents

Anesthesiologists are exposed to substantial occupational stress, making their psychological well-being essential for both personal health and optimal patient care. Early identification of mental health disorders among healthcare professionals is important for improving well-being and maintaining healthcare quality.

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Key information

Age range

20 year–35 year

Sex eligibility

All sexes

Study type

Observational

About this study

Although anesthesia residency is associated with considerable psychological stress, residents differ in how they respond to these challenges. While some develop psychological distress, others continue to perform effectively despite the demanding environment. These individuals, often described as "resilient" or "stress resistant," demonstrate successful adaptation to stress. The mechanisms underlying these individual differences remain incompletely understood. As with many aspects of psychological functioning, responses to stress are influenced by the combined effects of genetic predisposition and environmental experiences throughout life.

Among the biological markers investigated in recent years, the second-to-fourth digit (2D:4D) ratio has attracted considerable scientific interest because of its reported associations with a wide range of physical, behavioral, and psychological traits.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Any anesthesiologists who voluntarily agreed to participate in the study.
  • Age: 20-35 years
  • Both genders

Exclusion criteria

  • Incomplete questionnaires and/or irrelevant responses.
  • Injuries to the 2nd or 4th digits,
  • Unclear or inaccurate digit photocopy,
  • If the participant is a twin
  • Cumulative leave (e.g., maternity/sick leave) exceeding 6 months during the study period;
  • Pre-existing diagnosis of psychiatric disorders prior to the study

Treatment and study plan

Primary outcomes

  1. Anxiety score

    Time frame: Baseline (single assessment)

    Anxiety severity measured using the Penn State Worry Questionnaire (PSWQ). The PSWQ is a 16-item validated measure of the tendency toward excessive, uncontrollable worry, the cognitive hallmark of Generalized Anxiety Disorder. The association between anxiety score and digit measurement will be evaluated. Total scores range from 16 to 80, with higher scores indicating greater worry severity. A score ≥45 is commonly used as a clinical cutoff in research settings, with ≥60 strongly associated with Generalized Anxiety Disorder criteria.

Secondary outcomes

  1. Demographic data

    Time frame: Baseline (single assessment)

    Personal information, habits and health status

Sponsors and collaborators

Lead sponsor

Ain Shams University

Other

Registry information

Official study title

Association of Second-to-Fourth Digit Ratio (2D:4D) With Trait Anxiety and Occupational Stress Among Anesthesiology Residents: A Cross Sectional Observational Study

Important dates

Study start
2026
Primary completion
2026
Study completion
2026
First posted
Aug 11, 2026
Registry last updated
Aug 11, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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