Effect of Sage Extract Supplementation on Cognitive Function in Middle-Aged Men and Women

To evaluate the effects of sage extract (sageXtra™) on cognitive function and psychomotor performance in middle-aged men and women, subjects (40-60 years) will receive 333 mg of SageXtra or placebo daily for 8 consecutive weeks.

Inclusion criteria

• BMI 18.5-34.9 (inclusive) with a goal of being < 30 on average
• Subject agrees to maintain their existing dietary patterns throughout the study period.
• Subject agrees to refrain from alcohol, caffeine, and strenuous exercise for 24 hours before each test day.
• Subject is willing and able to comply with the study protocol.
• Has given voluntary, written, informed consent to participate in the study.

Exclusion criteria

• Individuals with a personal history of a psychiatric disorder.
• Individuals who are determined to have liver, renal, cardiovascular, or other metabolic disease.
• Current or recent (< 4 weeks) use of any dietary supplements (e.g., choline, lecithin, ginseng, ginkgo biloba, ashwagandha, Bacopa Monnieri, Paullina cupana, Rhodiola rosea, L-theanine, omega-3 fats, Prevagen, etc.), or currently prescribed medications (e.g., Adderall, Mydayis, Ritalin, Concerta, Mythylin, Provigil, Namenda), that may affect cognitive function (focus, concentration, memory, reaction time, energy, etc.).
• Alcohol consumption (>2 standard alcoholic drinks/day or >10 drinks/week) or drug abuse/dependence (including regular marijuana or THC use).
• Currently a smoker.
• Allergy or sensitivity to study product ingredients.
• Individuals who are cognitively impaired and/or who are unable to give informed consent.
• Any other condition which, in the PI's opinion, may adversely affect the subject's ability to complete the study, its measurements, or pose a significant risk to the subject.