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NCT Number: NCT07757347

Fructose and (Aging)

The aim of the present study is to investigate the effect of fructose consumption on health parameters and the intestinal barrier in healthy individuals

Recruiting

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Key information

Conditions

Intestinal Permeability Immune Response

Age range

18 year and older

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • all gender, healthy collective ≥ 18 years old

Exclusion criteria

  • Chronic inflammatory diseases of the gastrointestinal tract
  • Metabolic diseases or taking medication to treat metabolic diseases
  • Fructose malabsorption
  • Hereditary fructose intolerance
  • Food intolerances and/or allergies, as well as food allergies that require special dietary interventions
  • Special diets, such as vegetarian/vegan diets
  • Unstable body weight within the last 6 months (fluctuations of > 5%)
  • BMI < 19 kg/m2 & > 29,9 kg/m2
  • Bariatric surgery
  • Smoking
  • Liver diseases
  • Renal insufficiency
  • Rheumatoid arthritis
  • COPD with ≥ 2 exacerbations per year
  • Chronic pancreatitis or recurrent acute pancreatitis
  • Alcohol consumption above 10 g/d for women and above 20 g/d for men
  • Pregnancy and breastfeeding
  • Viral or bacterial infections that occurred no longer than 3 weeks ago

Treatment and study plan

Fructose

Other

Following a standardization of their nutritional intake for three days, participants will either receive a drink supplemented with low doses of free fructose (5%).

Other names: Diet

Glucose

Other

Following a standardization of their nutritional intake for three days, participants will either receive a drink supplemented with low doses of free glucose (5 %).

Other names: Diet

Primary outcomes

  1. Changes in markers of intestinal permeability

    Time frame: At the end of the treatment (1 month)

    Changes in concentrations of bacterial endotoxin in blood plasma

  2. Cytokine release from blood immune cells stimulated with bacterial toxins

    Time frame: At the end of the treatment (1 month)

    Changes in cytokine concentration in supernatant of immune cells before and after the treatments

Study contacts

Contact information is provided by the study sponsor or research team.

Ina Bergheim, Prof.

CONTACT

[email protected]

+43-1-4277-54981

Sponsors and collaborators

Lead sponsor

University of Vienna

Other

Registry information

Official study title

Investigation of the Effect of Fructose on Health Parameters and the Intestinal Barrier in Healthy Individuals

Acronym: FRUage

Important dates

Study start
2026
Primary completion
2027
Study completion
2027
First posted
Aug 11, 2026
Registry last updated
Aug 11, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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