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NCT Number: NCT07756775

Comparison Between Non-contrast Magnetic Resonance Angiography and Carotid Doppler in Cerebrovascular Stroke

This prospective observational study aims to compare the diagnostic performance of non-contrast magnetic resonance angiography (NC-MRA) and carotid Doppler ultrasonography in the evaluation of carotid artery disease among patients with ischemic cerebrovascular stroke or transient ischemic attack. A total of 200 adult patients presenting to Sohag University Hospital will undergo both imaging modalities. The study will assess the agreement between NC-MRA and carotid Doppler in detecting and grading carotid artery stenosis according to the NASCET criteria, with the goal of evaluating the clinical utility of each technique and optimizing imaging strategies for the assessment of cerebrovascular stroke.

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Key information

Conditions

Ischemic Stroke Arterial Occlusive Diseases Brain Diseases Brain Ischemia Cardiovascular Diseases Carotid Artery Diseases Carotid Artery Stenosis (Symptomatic and Asymptomatic) Carotid Stenosis Central Nervous System Diseases Cerebrovascular Disorders Ischemic Attack, Transient Nervous System Diseases Stroke Transient Ischemic Attack Vascular Diseases

Age range

18 year and older

Sex eligibility

All sexes

Study type

Observational

Primary location

Sohag University Hospital

Sohag, Sohag Governorate, 82524, Egypt

Location status: Recruiting

Location contact

Mohamed Saad Gad

CONTACT

[email protected]

+201112435154

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Adults aged 18 years or older.
  • Clinically diagnosed ischemic stroke or transient ischemic attack (TIA).
  • Imaging performed within 7-14 days of symptom onset.
  • Hemodynamically stable and suitable for magnetic resonance imaging (MRI).
  • Able and willing to provide written informed consent.

Exclusion criteria

  • Hemorrhagic stroke.
  • Previous carotid artery stenting.
  • Contraindications to MRI, including:
  • Non-MRI-compatible pacemakers or other MRI-incompatible implants.
  • Cochlear implants.
  • MRI-incompatible metallic orthopedic implants.
  • Severe claustrophobia.

Treatment and study plan

Primary outcomes

  1. Internal Carotid Artery Stenosis Grade (according to NASCET criteria) assessed by Non-contrast Magnetic Resonance Angiography and Carotid Doppler ultrasonography.

    Time frame: At the baseline imaging visit (within 7-14 days of symptom onset).

    Internal carotid artery stenosis grade in patients with ischemic stroke or transient ischemic attack determined according to the North American Symptomatic Carotid Endarterectomy Trial (NASCET) criteria using non-contrast magnetic resonance angiography and carotid Doppler ultrasonography. The stenosis grades obtained by the two imaging modalities will be compared.

Study contacts

Contact information is provided by the study sponsor or research team.

Mohamed Saad Gad

CONTACT

[email protected]

+201112435154

Sponsors and collaborators

Lead sponsor

Sohag University

Other

Registry information

Important dates

Study start
2026
Primary completion
2027
Study completion
2027
First posted
Aug 11, 2026
Registry last updated
Aug 11, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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