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NCT Number: NCT07756385

Comparison of Two Phacoemulsification Systems in Cataract Surgery (UNITY VCS vs. Centurion)

This prospective, randomized, contralateral (crossover) study compares the ultrasound efficiency and early postoperative outcomes (Day 1 and Day 7) of two phacoemulsification platforms - the UNITY® VCS system with 4D Phaco and the Centurion® Vision System with ACTIVE SENTRY® Handpiece - used in the two eyes of the same patient undergoing cataract surgery.

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Key information

Conditions

Cataract Surgery

Age range

18 year and older

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

University Eye Department, University Hospital Sveti Duh

Zagreb, 10000, Croatia

Location status: Recruiting

About this study

Adult patients scheduled for uncomplicated phacoemulsification with comparable cataract density between eyes (within one LOCS III grade) will have one eye randomized to the UNITY VCS system and the contralateral eye to the Centurion Vision System, with the same surgeon and using the same low IOP fluidics parameters. The contralateral eye surgery will be performed two weeks after the first eye surgery. The study will evaluate ultrasound efficiency using machine-recorded parameters, best-corrected visual acuity (BCVA), and central corneal thickness (CCT) on postoperative Days 1 and 7.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Adult patients scheduled for uncomplicated phacoemulsification with comparable cataract density between eyes (within one LOCS III grade)

Exclusion criteria

  • Prior corneal or intraocular surgery
  • Significant corneal pathology
  • Significant asymmetry between eyes in: cataract density, astigmatism, or axial length

Treatment and study plan

UNITY VCS SYSTEM ®

Device

4D PHACO PROBE

CENTURION VISION SYSTEM ®

Device

ACTIVE SENTRY PROBE

Primary outcomes

  1. Ultrasound efficiency evaluated through Cumulative Dissipated Energy (CDE) required to remove the cataract

    Time frame: Intraoperative

Secondary outcomes

  1. Ultrasound efficiency evaluated through Ultrasound (U/S) Total Time

    Time frame: Intraoperative

  2. Ultrasound efficiency evaluated through Total Aspiration Time

    Time frame: Intraoperative

  3. Ultrasound efficiency evaluated through Estimated Fluid Aspirated

    Time frame: Intraoperative

  4. Ultrasound efficiency evaluated through Total Case Time

    Time frame: Intraoperative

  5. Best-corrected visual acuity (BCVA)

    Time frame: Postoperative Day 1 and Day 7

  6. Central corneal thickness (CCT)

    Time frame: Postoperative Day 1 and Day 7

Other outcomes

  1. Ultrasound efficiency evaluated through number of Actuations (iS vs ASM)

    Time frame: Intraoperative

Interested in participating?

Recruiting

Interested in participating?

Request Info

Sponsors and collaborators

Lead sponsor

University Hospital Sveti Duh

Other

Registry information

Official study title

Comparison of Ultrasound Efficiency and Early Postoperative Outcomes of Two Phacoemulsification Systems (UNITY VCS 4D Phaco and Centurion With Active Sentry Probe): A Randomized Contralateral Eye Study

Acronym: COMPASS

Important dates

Study start
2026
Primary completion
2026
Study completion
2026
First posted
Aug 10, 2026
Registry last updated
Aug 10, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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