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NCT Number: NCT07756164

The Effects of a Multicomponent Sleep & Recovery Supplement on Muscle Fatigue and Sleep

The goal of this clinical trial (randomised crossover study) is to learn if a multi-component sleep and exercise recovery supplement can improve sleep quality and enhance recovery following exercise in healthy, recreationally active adults aged 18-40.

The main questions it aims to answer are:

1. Does the supplement reduce delayed onset muscle soreness (DOMS) following an intense exercise protocol? 2. Does the supplement improve sleep quality?

Researchers will compare the supplement to a placebo (a look-alike tablet with no active ingredients) to see if the supplement improves exercise recovery and sleep quality. In this crossover design, all participants will receive both the supplement and the placebo in separate 2-week periods, with a 2-week washout period in between.

Participants will:

* Take the supplement during one 2-week period and the placebo during another (order randomised), 30 minutes before bed each day * Complete an exercise protocol involving repeated leg extensions designed to induce muscle fatigue * Attend six laboratory visits, including baseline testing and follow-up assessments at 24 and 48 hours post-exercise * Complete daily sleep questionnaires during each supplementation period * Record food intake prior to exercise trials and replicate it for consistency * Perform muscle soreness assessments and single-leg jump tests before and after exercise, and during recovery

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Key information

Conditions

Age range

18 year–40 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Aged between 18-40, healthy and non smokers
  • Recreationally active, exercise at least 2 times a week

Exclusion criteria

  • • Not have any injuries that would affect performance
  • Not taking any medications that could affect drowsiness or energy levels
  • Not taking any other dietary supplements high in magnesium
  • Not be pregnant
  • Not have any illness or medical condition that could make intense exercise unsafe
  • Not be participating in other studies that could interfere with the outcomes of this study
  • Not have any current sleep problems e.g. Insomnia

Treatment and study plan

magnesium-based sleep & recovery supplement

Dietary Supplement

magnesium-based sleep & recovery supplement (2g/day for 2-weeks)

Placebo supplementation

Dietary Supplement

Placebo Supplementation (2g/day for 2-weeks)

Primary outcomes

  1. Changes in total work done

    Time frame: Following each 2-week supplementation period of either supplement

    Changes in total work done as measured by the Biodex

  2. Changes in work done (Flexion)

    Time frame: Following each 2-week supplementation period of either supplement

    Changes in work done (Flexion) as measured by the Biodex

  3. Changes in work done (Extension)

    Time frame: Following each 2-week supplementation period of either supplement

    Changes in work done (Extension) as measured by the Biodex

  4. Changes in Single Leg jump height

    Time frame: Before and Immediately After Muscle Damaging Protocol at the End of Each 2-Week Supplementation Period

    Changes in Single Leg jump height (m)

  5. Changes in Single Leg Jump hang time

    Time frame: Before and Immediately After Muscle Damaging Protocol at the End of Each 2-Week Supplementation Period

    Changes in Single Leg Jump hang time (s)

Secondary outcomes

  1. Changes in sleep quality

    Time frame: Following each 2-week supplementation period of either supplement.

    Changes in sleep quality as measured by the Groningen Sleep Quality questionnaire where a lower score indicates better sleep quality.

  2. Changes in perceived muscle soreness (Pain pressure threshold)

    Time frame: Following each 2-week supplementation period of either supplement and 24hr and 48hr following the muscle damaging protocol.

    Changes in perceived muscle soreness (Pain pressure threshold in Newtons) as measured by the muscle algometer where a higher score means a better outcome

  3. Change in Self-Reported Readiness to Train Score (5-Point Likert Scale)

    Time frame: Following each 2-week supplementation period of either supplement and 24hr and 48hr following the muscle damaging protocol

    Change in perceived readiness to train or compete assessed using a self-reported 5-point Likert scale, where 1 = not at all ready (extremely fatigued/sore) and 5 = completely ready (fresh, no limitations)

  4. Changes in Sleep Quality

    Time frame: Following each 2-week supplementation period of either supplement.

    Changes in Sleep Quality as measured by the Consensus Sleep Diary.

  5. Change in perceived recovery status (10-Point Likert Scale)

    Time frame: Following each 2-week supplementation period of either supplement and 24hr and 48hr following the muscle damaging protocol

    Change in perceived readiness to train or compete assessed using a self-reported 10-point Likert scale, where 0 = very poorly recovered and 10 = fully recovered

  6. Change in perceived overall muscle soreness (10-Point Likert Scale)

    Time frame: Following each 2-week supplementation period of either supplement and 24hr and 48hr following the muscle damaging protocol

    Change in perceived readiness to train or compete assessed using a self-reported 10-point Likert scale, where 0 = no soreness and 10 = worse soreness imaginable

Study contacts

Contact information is provided by the study sponsor or research team.

Tom G Gurney, PhD

CONTACT

[email protected]

+44 (0) 1326 370400

Sponsors and collaborators

Lead sponsor

University of Exeter

Other

Registry information

Official study title

The Effects of a Multicomponent Sleep & Recovery Supplement on Exercise Performance and Recovery Following a Muscle Damaging Protocol

Important dates

Study start
2026
Primary completion
2026
Study completion
2026
First posted
Aug 10, 2026
Registry last updated
Aug 10, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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