Healing After Injury to Reduce Opioid Use and Pain Through Preventive Engagement - Open Trial

The goal of this project is to refine the adaptive psychological intervention and assess initial feasibility and acceptability. Results will be used to inform a pilot randomized trial.

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Key information

Conditions

Pain Neurologic Manifestations Opioid Use Pathological Conditions, Signs and Symptoms Signs and Symptoms

Age range

18 year and older

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

Admitted to Henry Ford Hospital
Has an acute musculoskeletal injury
Prescribed opioids during the admission

Exclusion criteria

Under age 18
Cognitive impairment (i.e., diagnosis of delirium, dementia, or traumatic brain injury/Glasgow Coma Scale less than 13)
Chronic pain condition (i.e., pain most of the day, nearly every day for the past 3 months or longer)
Taking opioids 30 days or more prior to this hospitalization

Treatment and study plan

Psychological intervention

Behavioral

Participants will complete a computerized brief intervention (education about long-term opioid use and a mindfulness strategy) followed by four psychotherapy sessions composed of education, mindfulness, and acceptance-based strategies.

Primary outcomes

Acceptability of the intervention

Time frame: Post-intervention (40-day follow-up)

Percentage of participants that agreed/strongly agreed with items on the acceptability of intervention measure (AIM), intervention appropriateness measure (IAM), and feasibility of intervention measure (FIM).

Secondary outcomes

Treatment adherence

Time frame: Post-intervention (40-day follow-up)

Percentage of participants that attended at least 3 of 4 sessions
Study adherence

Time frame: Post-intervention (40-day follow-up)

Percentage of participants that completed the post-intervention assessment

Study contacts

Contact information is provided by the study sponsor or research team.

Lisa Matero, PhD

CONTACT

[email protected]

313-874-5454

Sponsors and collaborators

Lead sponsor

Henry Ford Health System

Other

Collaborators

National Institute on Drug Abuse (NIDA)

Registry information

Official study title

An Adaptive Psychological Intervention to Improve Pain and Reduce Opioid Use Following an Injury

Acronym: HOPE

Important dates

Study start: 2026
Primary completion: 2027
Study completion: 2027
First posted: Aug 10, 2026
Registry last updated: Aug 10, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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