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Completed

NCT Number: NCT07755306

Postoperative Pain After Dexamethasone Injection by Two Techniques in Irreversible Pulpitis

The aim of this randomized clinical trial to evaluate the effect of dexamethasone in two different techniques on postoperative pain by dividing patients randomly into three groups:

* Group I: buccinator injection of dexamethasone. * Group II: buccal infiltration of dexamethasone. * Group III (Control): IANB using local anesthesia only post operative pain will be evaluated subjectively by patients by VAS score after procedure immediately and follow up for 12, 24 and 72 hours and frequency of analgesic intake

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Key information

Age range

18 year–60 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Phase 4

Primary location

Faculty of Dentistry Ain Shams University

Cairo, Egypt

About this study

the previous studies used dexamethasone with LA to prolong the duration of nerve block , Dexamethasone is used in reducing intraoperative endodontic pain the study main aim is to overcome the problem of severe postoperative pain after endodontic treatment in patients with acute irreversible pulpitis by evaluating the effect of dexamethasone in two different techniques by giving dexamethasone injection of buccinator muscle, or dexamethasone as buccal infiltration, and comparing the results with inferior alveolar nerve block using local anesthesia only. pain score evaluated using VAS score preoperatively and postoperatively with different anesthetic techniques after endodontic treatment.and their effet on frequency of analgesic intake

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • 1- Both genders 2- Older than age of (18 to 60) years 3- Participants willing to commit for the entire period of the trial and agreed to sign the written consent after full explanation of the study 4- Having a mandibular molar tooth with vital pulp 5- These patients were also suffering from symptomatic irreversible pulpitis ,intermittent or continuous sharp pain that lasts longer after removal of the stimulus 6- Patients with moderate to severe symptoms VAS≥4

Exclusion criteria

  • 1- Vulnerable group; pregnant females, mentally ill and diseased patientsetc.… 2- Patients irritable to local anesthesia 3- Patients who are supposed to take plain anesthesia 4- Use of analgesic or antibiotic within 6 hours before the visit 5- Absence of bleeding in the pulp chamber during cavity preparation 6- Severe periodontal disease b- Patients' randomization, allocation and blinding:

Treatment and study plan

dexamethasone 8mg

Drug

8mg/2ml injected slowoly 30 sec for 1ml as single injection before the endotreatment

Primary outcomes

  1. visual analogue score (VAS) from 0 to 10

    Time frame: postoperative 72 hours

    VAS preoperative ,immediately postoperative,12hrs,24hrs,72hrs

Sponsors and collaborators

Lead sponsor

Ain Shams University

Other

Registry information

Official study title

Postoperative Pain in Patients With Symptomatic Irreversible Pulpitis After Using Dexamethasone in Combination With Local Anesthesia by Two Different Techniques (Randomized Clinical Trial)

Acronym: Dex/postop

Important dates

Study start
2024
Primary completion
2025
Study completion
2026
First posted
Aug 10, 2026
Registry last updated
Aug 10, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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