Skip to main content
OpenTrials
Recruiting

NCT Number: NCT07754149

Dose-Response Effects of a 6-Week Progressive Resistance Training Program on Premenstrual Syndrome in Adolescent Girls

This study examines the dose-response effects of a 6-week progressive resistance training program on premenstrual syndrome (PMS) in adolescent girls. PMS is a common condition that affects physical, psychological, and social well-being. While exercise is known to reduce symptoms, the optimal intensity of resistance training remains unclear. Using a randomized controlled trial design, participants are assigned to progressive or low-intensity training groups. PMS symptoms and quality of life are assessed over time. The study aims to determine whether higher exercise intensity leads to greater symptom reduction and improved overall well-being.

Recruiting

Interested in participating?

Request Info

Key information

Conditions

Premenstrual Syndrome Menstruation Disturbances Pathologic Processes Pathological Conditions, Signs and Symptoms

Age range

11 year–19 year

Sex eligibility

Female

Study type

Interventional

Phase

Not applicable

Primary location

Kens college model town humak and community model town, Islamabad, Federal, Pakistan

Loading trial locations.

About this study

This study focuses on premenstrual syndrome (PMS), a common cyclical condition experienced by adolescent girls that includes physical, psychological, and behavioral symptoms such as pain, mood swings, anxiety, fatigue, and reduced concentration. These symptoms can negatively affect academic performance, social interactions, and overall quality of life. Exercise has been shown to improve hormonal balance, reduce stress, and enhance mood through the release of endorphins and serotonin. However, most existing research has focused on aerobic exercise, with limited attention given to resistance training. Resistance training, which involves strengthening muscles through weights or bodyweight exercises, may offer additional benefits, but its optimal intensity and effectiveness for PMS management remain unclear. This study addresses this gap by examining the dose-response relationship of resistance training.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Diagnosed with Premenstrual Syndrome (PMS) based on PSST screening tool.
  • Not currently engaged in any structured resistance or exercise training program.
  • Medically cleared to participate in moderate-intensity resistance training.
  • Provided written informed consent for participation.

Exclusion criteria

  • Current use of hormonal therapy or oral contraceptives.
  • History of endocrine disorders (e.g., PCOS, thyroid dysfunction).
  • Any musculoskeletal or cardiovascular condition limiting exercise participation.
  • Ongoing psychiatric medication or diagnosed depression/anxiety disorder.
  • Participation in a structured exercise or resistance training program within the last 3 months.
  • Use of analgesics, anti-inflammatory, or hormonal medications during the study period.

Treatment and study plan

Progressive resistance training

Other

A supervised progressive resistance training program delivered three sessions per week for six weeks. Exercise intensity is gradually increased using the Borg Rating of Perceived Exertion (RPE) scale.

A warm up session will be done before resistance training exercise and Cool down for 5-10 minutes will be done exercise.

Participants will follow the FITT prescription for their resistance exercises.

Week 1-2 (DOSE 1) Intensity: Low. Bodyweight or dumbbells (RPE 7-11/20). Sets & Reps: 2 sets of 25-30 reps. Volume: High. Focus on mastering technique. Week 3-4 (DOSE 2) Intensity: moderate. Bodyweight or dumbbells (RPE 12-14/20). Sets & Reps: 2 sets of 20-25 repetitions. Volume: Moderate. Focus on mastering technique. Week 5-6(DOSE 3) Intensity: high. Dumbbells (RPE 15-16/20). Sets & Reps: 2 sets of 15-20 repetitions. Volume: Low.

Low-Intensity Resistance Training

Other

Participants of this group will receive the same standardized exercises as the experimental group. Exercise intensity remains constant at low intensity throughout the intervention period without progressive increase.

Before exercise the participants will perform warm up and after exercise they will perform cool down, same as the experimental group.

The FITT protocol for this group is as following:

Week 1-2 (DOSE1) Intensity: low Body weight. or Dumbbells (RPE 7-11/20). Sets & Reps: 2 sets of 15repetitions. Volume: Low. Focus on mastering technique. Week 3-4 (DOSE 2) Intensity: low. Bodyweight or dumbbells (RPE 7-11/20). Sets & Reps: 2 sets of 20 repetitions. Volume: Moderate. Focus on mastering technique Week 5-6(DOSE 3) Intensity: Low. Bodyweight or dumbbells (RPE 7-11/20). Sets & Reps: 2 sets of 25 reps. Volume: High. Focus on mastering technique.

Primary outcomes

  1. Premenstrual Symptoms Screening Tool (PSST)

    Time frame: Assessments will be conducted at baseline, week 2, week 4, week 6, and at 3-month follow-up

    The primary outcome of this study is the severity of premenstrual syndrome symptoms, measured using the Premenstrual Symptoms Screening Tool (PSST). The PSST is a self-reported questionnaire used to assess physical, psychological, and behavioral symptoms related to PMS, including mood swings, irritability, anxiety, fatigue, bloating, breast tenderness, and difficulty concentrating. It also evaluates how these symptoms affect daily activities, school performance, and social relationships. Each item is scored on a 4-point Likert scale ranging from "none" to "severe." Higher scores indicate greater PMS severity..

Secondary outcomes

  1. Quality of Life (QoL)

    Time frame: Quality of life will be assessed at baseline, immediately after the 6-week intervention, and at 3-month follow-up using the WHOQOL-BREF questionnaire.

    Quality of life will be assessed using the World Health Organization Quality of Life Questionnaire (WHOQOL-BREF). This questionnaire contains 26 items and evaluates four domains: physical health, psychological health, social relationships, and environmental well-being. Each item is rated on a 5-point Likert scale, with higher scores representing better quality of life. The WHOQOL-BREF is a reliable and valid tool commonly used in clinical and research settings to assess overall well-being.

Study contacts

Contact information is provided by the study sponsor or research team.

Dr Summra Andleeb, MS-OMPT

CONTACT

[email protected]

0345-0617872

Dr.Rida Zafar, MSWHPT

CONTACT

[email protected]

03368753273

Sponsors and collaborators

Lead sponsor

Riphah International University

Other

Registry information

Important dates

Study start
2026
Primary completion
2026
Study completion
2027
First posted
Aug 10, 2026
Registry last updated
Aug 12, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Related clinical trials

Published trials that share one or more normalized conditions with this study.