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NCT Number: NCT07753512

Effect of Different Adhesive Systems on White Spot Lesions During Fixed Orthodontic Treatment

The primary goal of this study is to compare the number of white spot lesions during fixed appliance therapy between self-etch and one-step bonding systems.

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Key information

Conditions

Malaligned Teeth Behavior Crowding Crowding of Teeth Spatial Behavior

Age range

12 year–30 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Foundation University College of Dentistry and Hospital

Islamabad, Federal, 44000, Pakistan

About this study

The aim of this study is to compare the number of white spot lesions that appear around bonded brackets between self-etch and one-step bonding systems using visual examination and to compare amount of demineralisation using DIAGNOdent scores.

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • healthy patients 12-30 yrs
  • patients undergoing fixed appliance treatment with full mouth bonding
  • presence of at least 7 accessible teeth
  • no cavitated lesion at time of bond up

Exclusion criteria

  • patients with chronic or systematic diseases
  • patients with fluorosis or enamel defects
  • presence of fixed prosthesis
  • patients on medications which could alter salivary flow
  • patients with history of salivary gland disease

Treatment and study plan

Self-etch adhesive

Combination Product

Self-Etch adhesive used for two step bonding of bracket placement.

One-Step Adhesive

Combination Product

Placement of bracket using one-step adhesive system.

Conventional Bonding Technique

Combination Product

Bonding brackets using three step conventional technique; etchant , bonding agent, composite adhesive

Primary outcomes

  1. Number of white spot lesions

    Time frame: From bracket placement to 6 months after placement.

  2. Demineralisation of bonded teeth

    Time frame: From date of bracket placement to 6 months of treatment

    Amount of demineralisation around brackets measured

Study contacts

Contact information is provided by the study sponsor or research team.

Emaan Ahsin

CONTACT

[email protected]

92 3065843663

Rozina Nazir

CONTACT

[email protected]

923215376612

Sponsors and collaborators

Lead sponsor

Foundation University Islamabad

Other

Registry information

Official study title

Effect of Different Adhesive Systems on White Spot Lesions During Fixed Orthodontic Treatment: A Split Mouth Randomized Controlled Trial

Important dates

Study start
2027
Primary completion
2028
Study completion
2028
First posted
Aug 7, 2026
Registry last updated
Aug 10, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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