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Completed

NCT Number: NCT07753434

Intraoperative Laser Speckle Imaging Predicts Early Renal Function After Kidney Transplantation

This observational study aims to explore the predictive value of intraoperative laser speckle contrast imaging for early postoperative renal function in kidney transplant recipients. The core research question is: What is the efficacy of intraoperative laser speckle contrast imaging in predicting early postoperative renal function among kidney transplant patients? This study will enroll kidney transplant patients who undergo intraoperative laser speckle contrast imaging and collect relevant evaluation data.

Last updated on February 27, 2025

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Key information

Conditions

Postoperative Renal Function

Sex eligibility

All sexes

Study type

Observational

Primary location

The Second Affiliated Hospital of Chongqing Medical University

Chongqing, Chongqing Municipality, 400010, China

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Patients undergoing renal transplantation in our hospital.

Exclusion criteria

  • Patients who need reoperation within 7 days after initial renal transplantation.
  • Patients with acute rejection within 24 hours after operation.

Treatment and study plan

Laser speckle contrast imaging (LSCI)

Device

Before abdominal closure, renal microcirculation was assessed using the RFLSI-ZW laser speckle contrast imaging (LSCI) system (RWD Life Science) which was mounted on a portable stand. The device was positioned 15-30 cm above the transplanted kidney, with the speckle lens aligned to the graft surface. Automatic focusing was applied to optimize image clarity, and images of the upper pole of the kidney were captured within a 15 × 15 cm field of view. 60 seconds of microcirculation imaging and perfusion curves were recorded at the upper pole of the kidney after reperfusion and immediately prior to abdominal closure (Figure 1). Perfusion Index (PI) was calculated using the software of the RFLSI-ZW LSCI system, which was closely related to the product of mean erythrocyte flow velocity and concentration within the tissue.

Primary outcomes

  1. Slow graft function (SGF)

    Time frame: Within 7 days after renal transplantation

Secondary outcomes

  1. Postoperative Cr

    Time frame: Within the first 7 postoperative days

  2. Postoperative BUN

    Time frame: Within the first 7 postoperative days

  3. Postoperative UO

    Time frame: Within the first 7 postoperative days

  4. Postoperative eGFR

    Time frame: Within the first 7 postoperative days

  5. Hospital length of stay

    Time frame: Up to 12 weeks

    The total length of hospital stay after renal transplantation.

Sponsors and collaborators

Lead sponsor

The Second Affiliated Hospital of Chongqing Medical University

Other

Registry information

Official study title

An Observational Study on the Predictive Value of Intraoperative Laser Speckle Contrast Imaging for Early Postoperative Renal Function in Kidney Transplant Recipients

Important dates

Study start
2024
Primary completion
2025
Study completion
2025
First posted
Aug 7, 2026
Registry last updated
Aug 7, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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