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NCT Number: NCT07753291

The Effects of the Yi Jin Jing on the Muscles and Bones of Adults

Observation of the effects of Yi Jin Jing on the muscles and bones of adults

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Key information

Age range

18 year–90 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

No. 23, Ganju Road, Dongcheng District, Beijing

Beijing, China

Location status: Recruiting

Location contact

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Age 18-90 years inclusive;
  • Generally healthy, no acute or chronic diseases affecting major organ functions;
  • No cognitive impairment, able to understand and comply with study procedures;
  • Willing and able to provide written informed consent;
  • No pregnancy or lactation (for females);
  • No recent (within 3 months) major surgery, hospitalization, or significant weight change (>5% body weight).

Exclusion criteria

  • Presence of acute or unstable chronic diseases (e.g., uncontrolled hypertension, diabetes, heart failure, or malignancy);
  • Severe cognitive impairment, psychiatric disorders, or inability to follow study instructions;
  • Recent (≤3 months) major surgery, trauma, or hospitalization;
  • Pregnancy, lactation, or childbearing potential without reliable contraception;
  • Body mass index (BMI) <16 or >40 kg/m²;
  • Current use of medications affecting muscle or nutritional metabolism (e.g., corticosteroids, anabolic steroids);
  • Participation in another interventional trial within 30 days.

Treatment and study plan

Yijinjing

Behavioral

Yijinjing

Primary outcomes

  1. Appendicular Skeletal Muscle Index

    Time frame: Day 180 ± 10 days

    Appendicular Skeletal Muscle Index (ASMI) = appendicular lean mass (kg) / height² (m²). It reflects muscle mass, used for sarcopenia diagnosis. Lower values indicate muscle loss, linked to aging, malnutrition, or disease.

Secondary outcomes

  1. Handgrip strength

    Time frame: Day 180 ± 10 days

    Handgrip strength (HGS) = maximum force (kg) measured by a dynamometer. It reflects overall muscle function, predicts disability, morbidity, and mortality. Low HGS indicates sarcopenia, frailty, or poor nutritional status.

  2. Nutrition intake form(MNA)

    Time frame: Day 180 ± 10 days

    Mini Nutritional Assessment - Short Form (MNA-SF) consists of 6 items:

    • Appetite and food intake - assesses whether food intake has decreased over the past 3 months.
    • Weight loss - records recent unintentional weight loss.
    • Mobility - determines whether the person can walk independently or is bedridden.
    • Acute disease or psychological stress - checks for stressful events in the past 3 months.
    • Neuropsychological problems - identifies dementia, depression, or other mental disorders that affect eating.
    • Body mass index (BMI) or calf circumference - reflects body fat reserves and muscle mass.

    Each item scores 0-3 points. A total score ≤11 indicates a risk of malnutrition. It is commonly used for nutritional screening in elderly populations.

  3. Fried

    Time frame: Day 180 ± 10 days

    Fried Frailty Phenotype = a 5-item scale assessing unintentional weight loss, exhaustion, low grip strength, slow walking speed, and low physical activity. item ≥3 = frail; 1-2 = prefrail; 0 = robust. Predicts falls, disability, and mortality.

  4. FRAIL

    Time frame: Day 180 ± 10 days

    FRAIL Scale = a 5-item questionnaire: Fatigue, Resistance (climb stairs), Ambulation (walk), Illness (≥5 chronic conditions), and Loss of weight (≥5%). Score 0 = robust, 1-2 = prefrail, 3-5 = frail. Quick screening for frailty in community settings.

  5. SPPB

    Time frame: Day 180 ± 10 days

    Short Physical Performance Battery (SPPB) = a 3-component test: standing balance (0-4), 4-meter gait speed (0-4), and 5-repetition chair stand (0-4). Total score 0-12; ≤8 indicates poor physical function, predicts disability, falls, and mortality in older adults.

  6. Muscle mass measured by ultrasound

    Time frame: Day 180 ± 10 days

    Ultrasound-based measurements of peripheral skeletal muscles offer a practical, non-invasive, and radiation-free approach for assessing muscle mass in clinical and research settings. In accordance with previously established cut-off values, the following parameters are employed to identify a tendency toward reduced muscle mass:

    • Biceps brachii cross-sectional area (CSA) - a male-specific indicator, with a value < 7.1 cm² suggesting reduced muscle mass;
    • Tibialis anterior muscle thickness (MT) - a female-specific indicator, with a value < 2.3 cm suggesting reduced muscle mass;
    • Rectus femoris muscle thickness (MT) - a gender-neutral rapid screening index, with a value < 1.3 cm serving as a universal cut-off for both men and women, indicating a tendency toward low muscle mass.

    These ultrasonographic parameters are intended for initial screening and may assist in the early identification of individuals at risk for sarcopenia, particularly when access to dual-energy X-ray abs

Study contacts

Contact information is provided by the study sponsor or research team.

jin he hejin

CONTACT

[email protected]

+8617600765734

Sponsors and collaborators

Lead sponsor

Beijing Hospital of Traditional Chinese Medicine

Other

Registry information

Important dates

Study start
2026
Primary completion
2027
Study completion
2028
First posted
Aug 7, 2026
Registry last updated
Aug 12, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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