Efficacy of Oral Nutritional Supplement in Community-Dwelling Adults Following Acute Care

Inclusion criteria

• At risk of malnutrition.
• At the point of hospital discharge, the admission was for an acute medical illness.
• Has low maximum handgrip strength.
• Estimated life expectancy of more than 12 months.
• Community ambulant.
• No other chronic disease.
• Able to communicate and follow instructions.
• Able to consume food and beverages orally.
• Willing to refrain from taking non-study oral nutritional supplements over the course of the study.
• Able and willing to follow study procedures.

Exclusion criteria

• Index hospitalization admission was for a surgical procedure or a stroke/myocardial infarction.
• Diagnosed with type 1 or type 2 diabetes.
• Has an active infectious disease.
• Diagnosed with severe gastrointestinal disorders.
• With severe or unstable congestive heart failure.
• With chronic kidney disease stage 2 or higher, end-stage organ failure, or other pre-terminal condition.
• Has an active malignancy within the past five years or currently receiving treatment for malignancy.
• Has a severe or unstable musculoskeletal or neuromuscular disorder.
• Unable to perform a valid handgrip strength assessment.
• Any condition that makes the participant unsuitable for the study.
• Currently enrolled in another clinical study.
• Has an eating disorder, alcoholism or substance abuse.
• Has dementia, delirium, or a significant neurological or psychiatric disorder.
• Known allergy or intolerance to any ingredients of the study product.
• Continuous use of ONS for 14 days prior to the baseline visit.
• Has used herbal products, dietary supplements, or medications in the past 30 days that could affect body weight, appetite, or body composition.
• Presence of clinically significant ascites, pleural effusion, edema, or dehydration.