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NCT Number: NCT07750756

Hyaluronic Acid vs I-PRF With Microneedling in Enhancing Peri-implant Soft Tissue

This study aims to compare the use of microneedling alone versus with hyaluronic acid or i-PRF in conjunction with microneedling in peri-implant mucosa in the esthetic zone to test the superior increase in gingival thickness.

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Key information

Age range

21 year–50 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Phase 2 / Phase 3

About this study

Despite the rising demand for esthetics and the prevailing use of dental implants in the recent era, the soft tissue remains a dilemma that affects patients' satisfaction and the implants' longevity in the oral environment, especially in the esthetic region of the maxilla. Various studies have been done to test the effectiveness of microneedling, hyaluronic acid, and i-PRF as alternative non-invasive or minimally invasive methods targeting tissue enhancement in the gingiva, and have proven that they have notable and desirable results. However, there is a lack in the literature regarding the use of these previously mentioned treatment options with regard to peri-implant soft tissue, and which of the delivered solutions offers superior results with reference to peri-implant mucosa in conjunction with microneedling.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Patients with delayed implants placed in the maxillary esthetic region in correct positioning and angulation
  • Patients with peri-implant gingival thickness ≤ 1 mm
  • Patients with healthy gingiva and who can maintain good oral hygiene around implants

Exclusion criteria

  • Marginal bone loss ≤ 2 mm
  • Patients with peri-implantitis or periodontitis
  • Patients with systemic conditions or diseases impairing healing or soft tissue metabolism
  • Pregnant or lactating females
  • Patients taking medications affecting the gingiva

Treatment and study plan

Hyaluronic Acid (HA)

Drug

Hyaluronic acid (HA) is a genuine linear glycosaminoglycan that is present within the extracellular matrix of connective, epithelial, and neural tissues.

Platelet rich fibrin

Biological

Injectable PRF (i-PRF) is a notable method in enhancing soft tissue phenotypes, relying on its injectable form that can be well delivered to targeted areas to ensure proper distribution of growth factors and cytokines.

Other names: (I-PRF)

Primary outcomes

  1. Peri-implant gingival thickness

    Time frame: 6 months

Study contacts

Contact information is provided by the study sponsor or research team.

Doaa A. Khattab, Associate Professor

CONTACT

[email protected]

+201006814258

Rahaf A. Khattab, Principal investigator

CONTACT

[email protected]

+201120008982

Sponsors and collaborators

Lead sponsor

Ain Shams University

Other

Registry information

Official study title

Hyaluronic Acid Versus I-PRF Combined With Microneedling for Peri Implant Soft Tissue Enhancement: A Randomized Controlled Clinical Trial

Important dates

Study start
2026
Primary completion
2028
Study completion
2028
First posted
Aug 6, 2026
Registry last updated
Aug 17, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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