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OpenTrials
Active, not recruiting

NCT Number: NCT07748234

Role of Anticoagulation in the Management of Tumor Thrombus

The purpose of this study is to conduct a retrospective review of oncology patients with a diagnosis of any solid tumor and lymphoma to identify a cohort with radiographically reported tumor thrombus or tumor compression of vasculature. Clinical and radiographic data will be collected on this cohort to understand the incidence and management of tumor thrombus or vascular compression, as well as relevant clinical outcomes, including bleeding, thrombus extension or embolism, and mortality.

Active, not recruiting

This study is active but is not currently recruiting participants.

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Key information

Conditions

Tumor Thrombus

Age range

0 month–40 year

Sex eligibility

All sexes

Study type

Observational

Primary location

Cincinnati Children's Hospital Medical Center

Cincinnati, Ohio, 45229, United States

About this study

Identify and characterize (by clinical, demographic, and radiographic data) pediatric and AYA solid tumor oncology patients with radiographic evidence of tumor thrombus.

Assess clinical outcomes (bleeding, thrombus resolution, thrombus extension or embolization, and mortality related to anticoagulation treatment vs non-treatment of identified tumor thrombus.

Identify and characterize pediatric and AYA solid tumor patients with a tumor compressing a vascular structure without thrombosis, as identified by review of radiographic reports.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

All Cincinnati Children's Hospital Medical Center (CCHMC) Oncology patients in the cancer registries (ACCRN07 CCHMC IRB #2008-1609 and the COG Registry CCHMC IRB # 2019-0616) identified as having a solid tumor and lymphoma (including osteosarcoma, Ewing sarcoma, Wilms tumor, hepatoblastoma, neuroblastoma, Hodgkin's and non-Hodgkin's lymphoma) diagnosis, and who, on review of radiographic study reports, have mention of tumor thrombus or vascular compression since January 01, 2010 - January 01, 2026, between the ages of 0 and 40 years old.

Exclusion criteria

Cancer diagnosis other than a lymphoma or solid tumor Absence of tumor thrombus or vascular compression mentioned in radiographic reports stored at CCHMC (EPIC © 2020 Epic Systems Corporation). Lack of medical records available at CCHMC for review

Treatment and study plan

Primary outcomes

  1. Anticoagulation or vascular intervention

    Time frame: Baseline through study completion, an average of 1 year

    Documentation in medical record of patient being placed on prophylactic or therapeutic anticoagulation or requiring therapeutic intervention (such as thrombectomy graft, stent, thrombolysis, or venoplasty)

  2. Clinical bleeding event

    Time frame: Baseline through study completion, an average of 1 year

    Major and clinically relevant non-major bleeding per ISTH definition

  3. Thrombus extension

    Time frame: Baseline through study completion, an average of 1 year

    Documented episode of thrombus extension or embolism, or bland thrombus formation

Secondary outcomes

  1. Stage of oncologic disease at diagnosis

    Time frame: Baseline through study completion, an average of 1 year

    As indicated by local vs metastatic disease spread

  2. New vs relapsed oncologic disease

    Time frame: Baseline through study completion, an average of 1 year

    Patient presenting with a new diagnosis vs relapsed disease when tumor thrombus identified

  3. Disease status at last follow up

    Time frame: Baseline through study completion, an average of 1 year

    a. Patient alive with no evidence of disease, alive with disease, dead of disease, died of other causes, lost to follow up

Sponsors and collaborators

Lead sponsor

Children's Hospital Medical Center, Cincinnati

Other

Registry information

Acronym: TUMOR THROMBUS

Important dates

Study start
2026
Primary completion
2026
Study completion
2027
First posted
Aug 5, 2026
Registry last updated
Aug 5, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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