Bone Marrow Imaging and Clinical Outcomes Across Hematologic, Oncologic, and Other Relevant Conditions

Primary Objective

To establish a longitudinal cohort integrating bone marrow imaging with clinical and treatment-related data.

Primary Endpoint

Successful enrollment of eligible participants and collection of relevant imaging and clinical data.

Secondary Objective

• Characterize bone marrow imaging findings across relevant patient populations.
• Evaluate relationships between imaging findings, treatment exposures, hematologic recovery, treatment-related toxicities, and clinical outcomes.
• Assess longitudinal changes in bone marrow imaging findings over time and following cancer therapy.
• Explore associations between imaging findings and laboratory, pathology, and research biomarker data when available.

Inclusion criteria

• Diagnosis of a hematologic, oncologic, or other condition relevant to the study.
• Availability of clinical, imaging, laboratory, treatment, and/or outcome data relevant to the study.
• Ability to provide informed consent for prospective participation or, for pediatric participants, parent/legal guardian permission with assent when applicable.
• Participants undergoing research MRI must be eligible for MRI according to institutional safety requirements.

Exclusion criteria

• Inability to provide required informed consent or parental/legal guardian permission for prospective participation.
• Insufficient clinical information to support study participation
• Pregnancy.
• Contraindication to MRI will exclude participants from research-specific MRI but not necessarily from other study components.