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NCT Number: NCT07743437

Relationship Between Frontal QRS-T Angle and Collateral Circulation in Coronary Artery Chronic Total Occlusion

• Aim of the work: To examine the relationship between collateral circulation and the frontal QRS-T angle in patients with chronic total occlusion (CTO)

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Key information

Age range

18 year and older

Sex eligibility

All sexes

Study type

Observational

Primary location

AssiutU

Asyut, Egypt

About this study

i. Study Objectives

  • Primary Objective:
  • To examine the relationship between coronary collateral circulation and the electrocardiographic frontal QRS-T angle in patients diagnosed with chronic total occlusion (CTO).
  • Secondary Objectives:
  • To identify other independent clinical and laboratory predictors (such as serum albumin levels and neutrophil counts) associated with an increased frontal QRS-T angle in patients with CTO.
  • To compare echocardiographic parameters (such as left ventricular ejection fraction and left ventricular dimensions) between patients with a normal QRS-T angle and those with an increased QRS-T angle.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Patients undergoing diagnostic coronary angiography due to stable angina persisting for a minimum duration of three months.
  • Patients diagnosed with total occlusion in at least one coronary artery, assessed to have chronic total occlusion (CTO) based on clinical and angiographic findings.

Exclusion criteria

  • Patients presenting with malignancies, atrial fibrillation, connective tissue disorders, hepatic failure, or renal failure.
  • A documented history of cardiac pacemaker implantation, prior bypass surgeries, or surgical valve replacements.
  • Congenital heart anomalies.
  • Patients receiving pharmacological interventions that affect ventricular repolarization (other than beta-adrenergic antagonists).
  • Individuals exhibiting abnormal electrolyte levels at the time of admission.

Treatment and study plan

12-lead Electrocardiogram (ECG) and Coronary Angiography

Diagnostic Test

A 12-lead ECG is performed to calculate the frontal QRS-T angle, and coronary angiography is performed to evaluate the coronary collateral circulation using the Rentrop Classification.

Primary outcomes

  1. correlation between frontal QRS-T angle and collateral circulation in CTO patients

    Time frame: baseline ( at the time of the diagnosis )

    • To examine the relationship between coronary collateral circulation and the electrocardiographic frontal QRS-T angle in patients diagnosed with chronic total occlusion (CTO).

Study contacts

Contact information is provided by the study sponsor or research team.

Hosam Hasan

CONTACT

Tarek Yaser

CONTACT

[email protected]

+201005094712

Sponsors and collaborators

Lead sponsor

Assiut University

Other

Registry information

Official study title

Frontal QRS-T Angle as an Electrocardiographic Marker for Collateral Circulation in Coronary Artery Chronic Total Occlusion

Important dates

Study start
2026
Primary completion
2028
Study completion
2028
First posted
Aug 3, 2026
Registry last updated
Aug 4, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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