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NCT Number: NCT07742189

Medication Collaboration Feasibility Study

This study examines the feasibility and acceptability of a brief medication collaboration intervention among older adults (age 60+) with early-stage dementia or mild cognitive impairment who take multiple medications and their family caregivers. The main aims are to: 1) determine the feasibility and acceptability of the intervention for older adults with early-stage dementia and their family caregivers, and 2) explore the effects of intervention on medication collaboration, medication adherence, and beliefs about dementia and autonomy.

In this study, participants will: 1) complete a 15-30-minute baseline interview (by Zoom or phone), 2) participate together in a 45-60-minute virtual intervention led by an interventionist that includes:

Assessment of medication responsibilities and beliefs. Education about dementia and medication management. Cognitive restructuring to address beliefs about independence and caregiver assistance.

Collaborative planning for medication responsibilities and routines; and lastly 3) complete a 15-20-minute one-month follow-up interview (by Zoom or phone) to assess the intervention's acceptability and changes in medication management outcomes.

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Key information

Conditions

Dementia Family Caregiver Behavior Brain Diseases Central Nervous System Diseases Dementia Health Behavior Medication Adherence Mental Disorders Nervous System Diseases Neurocognitive Disorders Patient Acceptance of Health Care Patient Compliance Treatment Adherence and Compliance

Age range

60 year and older

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

for older adults with dementia:

  • Age 60 or older
  • Diagnosis of dementia, Alzhimer's Disease or Mild Cognitive Impairment
  • Quick Dementia Rating Scale Score 2-12 (inclusive of mild cognitive impairment and mild dementia)
  • Taking 3 or more medications
  • Involved with managing their medications
  • Proficient speaking English
  • Capacity to provide consent

Inclusion criteria

for caregivers include::

  • Primary family caregiver for the past 3 months
  • Age 18 or older
  • Proficient speaking English

Exclusion criteria

  • adults unable to consent

Treatment and study plan

Medication Collaboration Intervention

Behavioral

A brief virtual behavioral intervention for older adults with early-stage dementia and their family caregivers designed to support collaborative medication management. The intervention includes: (1) assessment of beliefs about dementia, autonomy, and current medication responsibilities; (2) education on dementia progression and medication management; (3) reframing maladaptive beliefs regarding independence and caregiver assistance; and (4) collaborative development of implementation intentions and medication responsibility plans to facilitate medication adherence and the transition of medication management responsibilities. The intervention is delivered remotely via Zoom or telephone in a single 45-60-minute session by trained study interventionists.

Primary outcomes

  1. Acceptability of the Medication Collaboration Intervention

    Time frame: 1 Month

    Participant-reported acceptability of the intervention will be measured using The Acceptability of Intervention Measure, Intervention Appropriateness Measure, and Feasibility of Intervention Measure. Scale values range from 1 to 5 with a higher score indicating greater perceived acceptability of the Medication Collaboration Intervention.

Secondary outcomes

  1. Medication Collaboration

    Time frame: 1 Month

    Self-report of caregiver involvement with medications will be measured using an adapted version of the dyadic relationship scale. Scale scores range from 1-5 with a higher score indicating higher medication collaboration between caregiver and patient.

  2. Medication adherence

    Time frame: 1 Month

    Self-reported medication adherence via the Medication Adherence Scale. Responses are summed and averaged, with total scores ranging from 0-5, and higher scores indicating better adherence.

  3. Beliefs about dementia

    Time frame: 1 month

    Beliefs about dementia will be measured using the Representations and Adjustment to Dementia Index (RADIX) questionnaire. Individual items are scored, and scores range from 1-4.

  4. Medication Administration Hassles

    Time frame: 1 Month

    Caregiver reported medication administration hassles will be measured using The Family Caregiver Medication Administration Hassles Scale. We will use the Logistics subscale. The total score ranges from 0-35, with higher scores indicating greater perceived hassle associated with managing the logistics of another person's medication regimen

  5. Beliefs about independence with medicines

    Time frame: 1 month

    Beliefs about independence with medicines will be self reported using individual items. We will use report the frequency of agreement with individual items, where greater agreements indicates stronger beliefs in the importance of medication autonomy and independence.

Study contacts

Contact information is provided by the study sponsor or research team.

Dianne Oladejo

CONTACT

[email protected]

3125036452

Rachel O'Conor

CONTACT

[email protected]

13125033240

Sponsors and collaborators

Lead sponsor

Northwestern University

Other

Registry information

Official study title

Feasibility Study of a Brief Intervention to Support Medication Collaboration Among Older Adults and Family Care Partners

Important dates

Study start
2026
Primary completion
2026
Study completion
2026
First posted
Aug 3, 2026
Registry last updated
Aug 14, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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