A Clinical Trial of Nemtabrutinib in Participants With Severe Kidney Disease (MK-1026-027)

Inclusion criteria

The main inclusion criteria include but are not limited to the following:

All participants:

• Has a body mass index (BMI) ≥18.0 and ≤40.0 kg/m^2

Participants with Severe Renal impairment (RI):

• The participant has stable renal function as determined by historical measurements.

Healthy volunteers:

• Is medically healthy with no clinically significant medical history

Exclusion criteria

The main exclusion criteria include but are not limited to the following:

Renal Impairment Participants:

• History of any illness, other than renal impairment, that, in the opinion of the investigator, might confound the results of the study or poses an additional risk to the participant by their participation in the study.

Healthy Matched Control Participants:

• History of clinically significant endocrine, gastrointestinal, cardiovascular, hematological, hepatic, immunological, renal, respiratory, genitourinary, or major neurological (including stroke and chronic seizures) abnormalities or diseases. Participants with a remote history of uncomplicated medical events (eg, uncomplicated kidney stones, as defined as spontaneous passage and no recurrence in the last 5 years, or childhood asthma) may be enrolled in the study at the discretion of the investigator