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NCT Number: NCT07726758

The Effectiveness of Squat Exercise for Improving Pre-Sarcopenia in Order Adults

With the growing aging population, it has been reported that approximately 10-20% of older adults have pre-sarcopenia. Pre-sarcopenia is defined as a decline in either muscle mass or muscle strength. Previous studies have indicated that squat exercise has significant effects on improving lower-extremity muscle strength and physical performance. Early intervention through resistance exercise during the pre-sarcopenia stage may increase muscle mass, enhance physical performance, and prevent progression to sarcopenia. Therefore, the purpose of this study is to investigate the effects of squat exercise on improving pre-sarcopenia among older adults. It is expected that, following the squat exercise intervention, older adults will demonstrate significant improvements in muscle mass, lower-extremity muscle strength, physical performance, and body composition, thereby alleviating pre-sarcopenia.

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Key information

Conditions

Sarcopenia Atrophy Muscular Atrophy Nervous System Diseases Neurologic Manifestations Neuromuscular Manifestations Pathological Conditions, Anatomical Pathological Conditions, Signs and Symptoms Signs and Symptoms

Age range

65 year–100 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Hsiao-Chien,Tseng

Taipei, Taiwan

Location status: Recruiting

Location contact

HSIAO-CHIEN TSENG, MASTER

CONTACT

[email protected]

0910861224

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Older adults aged 65 years and above who meet at least one criterion of pre-sarcopenia.
  • Residents of Hualien.
  • Able to read, have clear consciousness, and communicate in Mandarin.
  • Willing to participate in this study.

Exclusion criteria

  • Individuals with disability.
  • Individuals with psychiatric disorders or other conditions affecting cognitive function.
  • Individuals with injuries of the knee, hip, or lumbar spine that prevent participation in squat exercise.

Treatment and study plan

Squat Exercise

Behavioral

Squat exercise is an effective resistance training intervention that enhances lower-extremity muscle strength, physical performance, and functional ability, thereby helping prevent or delay sarcopenia in older adults.

Primary outcomes

  1. Physical performance assessed by the Short Physical Performance Battery (SPPB)

    Time frame: Baseline, 6 weeks, and 12 weeks

    Physical performance will be assessed using the Short Physical Performance Battery (SPPB). The SPPB consists of three components: balance test, gait speed test, and chair stand test. Total scores range from 0 to 12 points, with higher scores indicating better physical performance

  2. Body composition assessed by bioelectrical impedance analysis (InBody)

    Time frame: Baseline, 6 weeks, and 12 weeks

    Body composition will be assessed using bioelectrical impedance analysis (InBody).Measurements include skeletal muscle mass, body fat mass, and body fat percentage.

Study contacts

Contact information is provided by the study sponsor or research team.

HSIAO-CHIEN TSENG, MASTER

CONTACT

[email protected]

0910861224

Sponsors and collaborators

Lead sponsor

Tzu Chi University

Other

Registry information

Important dates

Study start
2026
Primary completion
2026
Study completion
2028
First posted
Jul 24, 2026
Registry last updated
Jul 24, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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