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Completed

NCT Number: NCT07717918

A Study of BL1332 on Capsaicin-Induced Ocular Pain in Healthy Trial Participants

Single center, double-masked study of BL1332 on Capsaicin-Induced Ocular Pain in Healthy Subjects

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Key information

Conditions

Healthy

Age range

18 year–65 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Phase 1

Primary location

Site 101

Newport Beach, California, 92663, United States

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Male or female ≥ 18 to ≤ 65 years of age.
  • In good health, as assessed at Screening by the Investigator from past medical history, physical examination (abbreviated), and laboratory tests.
  • Does not wear contact lenses, or is willing to refrain from wearing contact lenses for the duration of the study.

Exclusion criteria

  • Women of childbearing potential or non-vasectomized males with partners of childbearing potential are not eligible unless they are using an effective method of contraception and agree to use an effective method of contraception until at least 30 days after study treatment.
  • Any medical condition (systemic or ophthalmic) that may, in the opinion of the Investigator, preclude the safe administration of IP, safe participation in this study, or confound the assessment of safety or efficacy.
  • Unwilling or unable to comply with the study protocol.

Treatment and study plan

BL1332 eye drops

Drug

Taken 1 time

BL1332 Placebo eye drops

Drug

Taken 1 time

Primary outcomes

  1. Ocular pain severity assessed by numeric pain rating scale (NPRS)

    Time frame: Assessed 5 seconds post-capsaicin dose

    NPRS scale 0 to 10, with higher score reflecting worse pain

Sponsors and collaborators

Lead sponsor

Bausch & Lomb Incorporated

Industry

Registry information

Official study title

A Phase 1B Study of BL1332 on Capsaicin-Induced Ocular Pain in Healthy Subjects

Important dates

Study start
2026
Primary completion
2026
Study completion
2026
First posted
Jul 21, 2026
Registry last updated
Sep 10, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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