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NCT Number: NCT07647146

Corneal Epithelial Thickness Mapping by Anterior Segment Optical Coherence Tomography in Patients With Refractive Errors

This study evaluates corneal epithelial thickness using anterior segment optical coherence tomography (AS-OCT) in patients with refractive errors. It aims to assess the relationship between epithelial thickness patterns and different types of refractive errors.

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Key information

Conditions

Myopia Astigmatism Corneal Diseases Emmetropia Eye Diseases Hyperopia Refractive Errors

Age range

18 year–99 year

Sex eligibility

All sexes

Study type

Observational

Primary location

Sohag University Hospital

Sohag, Sohag Governorate, 82524, Egypt

About this study

Refractive errors are among the most common ocular conditions affecting visual acuity. Corneal epithelial thickness has been suggested to play a role in the optical properties of the eye and may vary among different refractive states. This observational study aims to evaluate corneal epithelial thickness mapping using anterior segment optical coherence tomography (AS-OCT) in patients with refractive errors. Patients will be assessed and categorized according to their refractive status, and epithelial thickness measurements will be obtained and analyzed. The study seeks to investigate potential correlations between epithelial thickness distribution and different types of refractive errors to enhance understanding of corneal biomechanics in refractive conditions.

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Age ≥ 18 years-
  • Patients diagnosed with myopia or hyperopia by refraction
  • Clear cornea with no evidence of corneal pathology
  • Ability to undergo reliable anterior segment imaging

Exclusion criteria

  • Inability to fixate or follow instructions
  • Family history of keratoconus
  • Glaucoma,Cataract
  • Previous ocular surgery including refractive surgery
  • Keratoconus or suspected corneal ectasia
  • Corneal opacities or scars
  • Contact lens wear within the last two weeks
  • Ocular trauma
  • systemic disease affecting the cornea ( Such as diabetes)

Treatment and study plan

Primary outcomes

  1. Measurement of corneal epithelial thickness using AS-OCT

    Time frame: At baseline during a single study visit when participants undergo AS-OCT examination.

    Corneal epithelial thickness will be measured using anterior segment optical coherence tomography (AS-OCT). Measurements will include central and regional epithelial thickness values in microns in patients with different refractive errors.

Secondary outcomes

  1. Comparison of epithelial thickness between myopic and hyperopic eyes

    Time frame: At baseline (single visit)

    Corneal epithelial thickness will be compared between myopic and hyperopic eyes using AS-OCT measurements.

  2. Comparison of epithelial thickness in eyes with and without astigmatism

    Time frame: At baseline (single visit)

    Corneal epithelial thickness will be evaluated and compared between eyes with astigmatism and those without astigmatism using AS-OCT.

  3. Corneal epithelial thickness asymmetry across corneal regions and inter-eye comparison

    Time frame: At baseline (single visit)

    Epithelial thickness will be assessed across different corneal regions and compared between both eyes to evaluate inter-eye asymmetry.

  4. Comparison of epithelial thickness in low and high refractive errors

    Time frame: At baseline (single visit)

    Corneal epithelial thickness profiles will be compared between low and high degrees of myopia and hyperopia using AS-OCT measurements.

Interested in participating?

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Sponsors and collaborators

Lead sponsor

Sohag University

Other

Registry information

Important dates

Study start
2026
Primary completion
2027
Study completion
2027
First posted
Jun 15, 2026
Registry last updated
Jun 15, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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