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NCT Number: NCT07579130

Comparative Assessment of Lipid Layer Thickness Measurements

This study compares ocular lipid layer thickness (LLT) measurements obtained from three commonly used clinical diagnostic devices to evaluate their agreement and consistency. It further examines which device's LLT measurements show the strongest correlation with established clinical indicators of dry eye disease severity.

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Key information

Conditions

Dry Eye Dry Eye Syndromes Eye Diseases Lacrimal Apparatus Diseases

Age range

18 year–100 year

Sex eligibility

All sexes

Study type

Observational

Primary location

Atwater Eye Care Center

Bloomington, Indiana, 47405, United States

Location status: Recruiting

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Dry eye disease

Exclusion criteria

  • None

Treatment and study plan

LipiView

Device

Subjects will undergo lipid layer thickness measurement

Omnicad

Device

Subjects will undergo lipid layer thickness measurement

Bruder Ocular Surface Analyzer

Device

Subjects will undergo lipid layer thickness measurement

Primary outcomes

  1. Lipid Layer Thickness

    Time frame: measurements taken at single visit, baseline

    Average and minimum lipid layer thickness measurements will be compared across devices

Secondary outcomes

  1. Correlation with dry eye clinical measurements

    Time frame: measurements taken at single visit, baseline

    Correlations will be compared and analyzed with clinical dry eye measuremetns

Interested in participating?

Recruiting

Interested in participating?

Request Info

Sponsors and collaborators

Lead sponsor

Indiana University

Other

Registry information

Official study title

Comparative Assessment of Lipid Layer Thickness Measurements Across Three Devices and Their Correlation With Clinical Indicators in Dry Eye Disease

Important dates

Study start
2026
Primary completion
2028
Study completion
2028
First posted
May 11, 2026
Registry last updated
May 11, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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