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NCT Number: NCT07566676

Maxillary Incisor Intrusion Using Utility Arch Assisted With Micro-osteoperforations

Study will be directed to evaluate the dentoalveolar changes following maxillary incisor intrusion using utility arch assisted with micro-osteoperforations in deep bite cases.

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Key information

Conditions

Deep Bite Malocclusion Intrusion of Tooth Orthodontic Tooth Movement Root Resorption Stomatognathic Diseases Tooth Diseases Tooth Resorption

Age range

15 year–25 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Faculty of Dental Medicine (Boys), Al-Azhar University

Cairo, Nasr City, 4434103, Egypt

Location status: Recruiting

About this study

Micro-osteoperforations (MOPs) are a new, simple, and minimally invasive technique to accelerate tooth movement. The biologic mechanism behind MOPs is to increase the cytokine expression that leads to increased bone resorption, the catabolic phase of tooth movement, in the direction of tooth movement. Transmucosal holes in cortical bone are made to trigger bone remodeling changes for faster tooth movement and decrease root resotption.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Patients age between 15-25 years.
  • Patients with overbite ≥ 4 mm.
  • All permanent teeth erupted (excluding 3rd molars).
  • No previous orthodontic treatment.
  • Patients with good oral hygiene and good periodontal health.

Exclusion criteria

  • Skeletal discrepancies.
  • Missing maxillary anterior teeth or any kind of tooth/root shape anomaly.
  • Patients with root resorption or impacted canines.
  • Previous history of orthodontic treatment.
  • Systemic disease interferes with orthodontic tooth movement.
  • History of trauma affecting the maxillary incisors.
  • Poor oral hygiene or periodontally compromised patient.
  • Endodontically treated upper anterior teeth.

Treatment and study plan

Micro-osteoperforations

Procedure

Using utility arch with micro-osteoperforations (MOPs). The biologic mechanism behind MOPs is to increase the cytokine expression that leads to increase bone resorption and the catabolic phase of tooth movement in the direction of tooth movement. Transmucosal holes in cortical bone are made to trigger bone remodeling changes for faster tooth movement at the apices above maxillary incisors to evaluate the amount of movement and amount of root resorption.

Other names: MOPs

Utility arch

Device

Patients will receive utility arch for intrusion of maxillary incisors without micro-osteoperforations.

Primary outcomes

  1. Amount of root resorption

    Time frame: Up to 6 months or correction of deep bite

  2. Marginal bone level changes

    Time frame: Up to 6 months or correction of deep bite

Secondary outcomes

  1. Amount of intrusion of maxillary incisors

    Time frame: Up to 6 months or correction of deep bite

Interested in participating?

Recruiting

Interested in participating?

Request Info

Sponsors and collaborators

Lead sponsor

Al-Azhar University

Other

Registry information

Official study title

Evaluation of Dentoalveolar Changes Following Maxillary Incisor Intrusion Using Utility Arch Assisted With Micro-osteoperforations in Deep Bite Cases: A Randomized Clinical Trial

Acronym: MOPs

Important dates

Study start
2026
Primary completion
2028
Study completion
2029
First posted
May 5, 2026
Registry last updated
May 5, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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