Microbiome-targeted Diet Therapy in Ulcerative Colitis

Inclusion criteria

• Ability and willingness to provide informed consent
• Age at least 18 years old
• Diagnosis of UC based on clinical and endoscopic criteria
• UC duration of at least 3 months
• Ulcerative Colitis Endoscopic Index of Severity (UCEIS) score ≤4 within 90 days of randomization
• On a stable dose or no existing UC therapies (apart from steroids) for defined periods (as outlined below).

• ≥4 weeks if no medication, 5-ASA
• ≥8 wk for immunomodulatory therapy
• ≥12 wk for biologics
• Ability to comply with study requirements in the opinion of the primary investigator

Exclusion criteria

• Moderate or severe UC as defined by UCEIS ≥5
• History of stomach surgery or bowel resection
• Antibiotic use within 3 months
• Anticipated antibiotic exposure during the study period (e.g. perioperative antibiotics)
• Pregnancy or breastfeeding
• History of anaphylactic food allergies
• Intolerance of high dietary fiber content
• Ongoing alcohol or drug abuse
• Habitual vegan diet pattern
• Insufficient freezer space to accommodate meal delivery