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NCT Number: NCT07507877

Infraclavicular Axillary Vein Collapsibility Index as a Predictor of Fluid Responsiveness

Fluid responsiveness refers to the ability of the left ventricle to significantly increase stroke volume following fluid administration, and its assessment is critical in managing acute circulatory failure while avoiding fluid overload.Infraclavicular axillary vein collapsibility index is a substitute for inferior vena cava collapsibility index in assessment for the need of fluid resuscitation in spontaneously breathing sepsis related acute circulatory failure patients.

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Key information

Conditions

Sepsis Infections Inflammation Pathologic Processes Pathological Conditions, Signs and Symptoms Systemic Inflammatory Response Syndrome

Age range

18 year and older

Sex eligibility

All sexes

Study type

Observational

Primary location

Ain-Shams University Hospitals

Cairo, Egypt

Location status: Recruiting

Location contact

Ibrahim Mamdouh Esmat

CONTACT

[email protected]

01001241928

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Adult patients ≥18 years.
  • Patients with sepsis must meet at least two or more criteria of systemic inflammatory response syndrome (SIRS).
  • Spontaneously breathing patients.
  • Clinical signs of acute circulatory failure.

Exclusion criteria

  • Patients below the age of 18 years.
  • Mechanically ventilated patients

Treatment and study plan

Infraclavicular axillary vein collapsibility index

Other

Assessment of the infraclavicular axillary vein collapsibility index to predict fluid responsiveness in spontaneously breathing patients in sepsis related acute circulatory failure.

Primary outcomes

  1. The infraclavicular axillary vein collapsibility index changes in response to fluid challenge.

    Time frame: Fluid challenge over 10 min time period.

    The infraclavicular axillary vein collapsibility index changes in response to fluid challenge. A collapsibility index greater than fifty percent in spontaneously breathing patients is commonly associated with a right atrial pressure between zero and five millimeters of mercury.

Study contacts

Contact information is provided by the study sponsor or research team.

Ibrahim Mamdouh Esmat

CONTACT

[email protected]

01001241928

Sponsors and collaborators

Lead sponsor

Ain Shams University

Other

Registry information

Official study title

Infraclavicular Axillary Vein Collapsibility Index as a Predictor of Fluid Responsiveness in Spontaneously Breathing Patients in Sepsis-related Acute Circulatory Failure: a Prospective Observational Study

Important dates

Study start
2026
Primary completion
2026
Study completion
2026
First posted
Apr 2, 2026
Registry last updated
Apr 15, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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