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NCT Number: NCT07496645

EFFECT OF ANODAL TRANSCRANIAL DIRECT CURRENT STIMULATION ON NAMING IN APHASIC PATIENTS WITH ACUTE ISCHEMIC STROKE

The use of transcranial direct current stimulation (tDCS) for the management of deficits developed in stroke is a relatively new type of management option. Many of the studies performed using tDCS have focused on improvements noted in hemiplegia as compared to aphasia, which is an equally disabling outcome of strokes. The results of these studies have not been conclusive and concordant with each other.

In aphasia management, the majority of the studies have focused on chronic strokes. Since the use of tDCS is relatively new, the studies have not focused on a particular type of deficit or stroke. Very few studies have focused on the impact of solely using tDCS. Very few studies have focused on acute to subacute strokes. The results of the studies have, nevertheless, been encouraging.

Improvements in aspects of language tested after a single session of tDCS are short-lived. There is an unmet need to probe the utility of repetitive tDCS on aspects of language function in patients who are aphasic due to acute stroke. There is also a paucity of data in the Indian scenario regarding the same.

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Key information

Conditions

Acute Ischemic Cerebrovascular Disease Aphasia Aphasia Following Cerebral Infarction Aphasia, Acquired Communication Disorders Language Disorders Nervous System Diseases Neurobehavioral Manifestations Neurologic Manifestations Pathological Conditions, Signs and Symptoms Post Stroke Aphasia Signs and Symptoms Speech Disorders

Age range

18 year–65 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Phase 3

Primary location

Atal Bihari Vajpayee Institute of Medical Sciences and Dr. Ram Manohar Lohia Hospital, New Delhi

New Delhi, National Capital Territory of Delhi, 110001, India

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Aphasic patients with left middle cerebral artery territory Acute Ischemic Stroke
  • Patients between 18-65 years of age.
  • Within 5 days of onset of stroke.

Exclusion criteria

  • Patients with malignant Middle Cerebral Artery territory infarcts and previous clinical history of cerebral hemisphere stroke.
  • Patients with history of previous brain surgery or skull defect due to surgery e.g. craniectomy.
  • Patients with epilepsy.
  • Patients with history of significant head trauma in the last 1 month.
  • Patients with documented history of major depression prior to stroke.
  • Patients with alcohol/drug abuse in the past 6 months.
  • Patients with prior significant cognitive impairment.
  • Pacemaker in situ, cochlear implant in situ.
  • Pregnancy.

Treatment and study plan

Transcranial Direct Current Stimulation

Device

Anodal tDCS

Primary outcomes

  1. Primary Outcome: Difference of change in Accuracy between Anodal tDCS group and Sham tDCS group at 5 days

    Time frame: at 5 days after tDCS

    Accuracy is defined as the number of words spoken without the help of a semantic or phonemic cue on the ICMR Picture Naming Test

  2. Co-Primary outcome: Difference of change in Reaction Time between Anodal tDCS group and Sham tDCS group at 5 days

    Time frame: at 5 days after tDCS

    Reaction times were documented in milliseconds.

Secondary outcomes

  1. Difference of change in Correct Response between Anodal tDCS group and Sham tDCS group at 5 days

    Time frame: at 5 days after tDCS

    Correct Response is defined as the total number of words spoken, with or without the help of either a semantic or a phonemic cue on the ICMR Picture Naming Test.

  2. Difference of change in PNT Score between Anodal tDCS group and Sham tDCS group at 5 days

    Time frame: at 5 days after tDCS

    PNT scores are recorded as per the guidelines of the ICMR Picture Naming Test

  3. Difference of change in Accuracy between Anodal tDCS group and Sham tDCS group at 4 weeks

    Time frame: at 4 weeks after tDCS

    Accuracy is defined as the number of words spoken without the help of a semantic or phonemic cue on the ICMR Picture Naming Test

  4. Difference of change in Reaction Time between Anodal tDCS group and Sham tDCS group at 4 weeks

    Time frame: at 4 weeks after tDCS

    Reaction times were documented in milliseconds.

  5. Difference of change in Correct Response between Anodal tDCS group and Sham tDCS group at 4 weeks

    Time frame: at 4 weeks after tDCS

    Correct Response is defined as the total number of words spoken, with or without the help of either a semantic or a phonemic cue on the ICMR Picture Naming Test.

  6. Difference of change in PNT Score between Anodal tDCS group and Sham tDCS group at 4 weeks

    Time frame: at 4 weeks after tDCS

    PNT scores are recorded as per the guidelines of the ICMR Picture Naming Test.

Interested in participating?

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Sponsors and collaborators

Lead sponsor

Dr. Ram Manohar Lohia Hospital

Other Gov

Registry information

Important dates

Study start
2026
Primary completion
2026
Study completion
2026
First posted
Mar 27, 2026
Registry last updated
Mar 27, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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