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NCT Number: NCT07467265

The Rapid Shallow Breathing Index (RSBI) is a Widely Used Predictor for Weaning Patients From Mechanical Ventilation This Study Aims to Determine the Predictive Value of RSBI Measurements for Extubation Success in Mechanically Ventilated ICU Patients

Early extubation in ICU patients is crucial for reducing complications of prolonged ventilation, including morbidity and mortality. The Rapid Shallow Breathing Index (RSBI) is a widely used predictor for weaning patients from mechanical ventilation. This study aims to determine the predictive value of RSBI measurements for extubation success in mechanically ventilated ICU patients

Recruiting

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Key information

Conditions

Ventilated Patient in Intensive Care Failure of Extubation

Age range

22 year and older

Sex eligibility

All sexes

Study type

Observational

Primary location

Ain Shams Hospital

Cairo, Abbasia, 1181, Egypt

Location status: Recruiting

Location contact

Sarah Elghareeb

CONTACT

[email protected]

01012434690

About this study

The extubation decision is a combined clinical judgment based on a passing Spontaneous Breathing Trial (SBT) and a Rapid Shallow Breathing Index (RSBI) value ≤ 105 breaths/min/L.combination of criteria (SBT + RSBI threshold) This approach is recommended to improve predictive accuracy, as neither SBT nor RSBI alone is perfectly reliable.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • • Adults > 22 years.
  • Mechanically ventilated patients meeting extubation readiness:
  • FiO₂ ≤ 0.4, PEEP ≤ 8 cmH₂O, PaO₂/FiO₂ ≥ 200 mmHg.
  • Respiratory rate ≤ 35 breaths/min, pH > 7.30.
  • Hemodynamic stability (HR ≤ 120 bpm, SBP 90-160 mmHg).
  • Glasgow Coma Scale >10, adequate cough reflex.
  • Includes postoperative, elective/emergency reintubation, and tracheostomized patients.

Exclusion criteria

  • Age <22 years.
  • Refusal of informed consent.
  • Altered mental status (e.g., traumatic brain injury).
  • Hemodynamic instability or deep sedation (RASS ≤ -2).

Treatment and study plan

Primary outcomes

  1. Extubation success (no reintubation/adjuvant support within 48h).

    Time frame: 48 hour

    no reintubation or adjuvant oxygen therapy

Study contacts

Contact information is provided by the study sponsor or research team.

Sarah hamdy Elghareeb, MD

CONTACT

[email protected]

+201012434690

Sponsors and collaborators

Lead sponsor

Ain Shams University

Other

Registry information

Official study title

Rapid Shallow Index as Successfully Predictor of Outcome of Extubating

Important dates

Study start
2026
Primary completion
2026
Study completion
2026
First posted
Mar 12, 2026
Registry last updated
Mar 13, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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