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NCT Number: NCT07465003

Cohort Study of Chronic Liver Disease Complicated by Sepsis

Study population: Patients with liver cirrhosis complicated by sepsis Observation indicators: Fluid resuscitation strategy, early dynamic indicators such as MAP Observation endpoint: 28-day all-cause mortality Study design: Retrospective cohort study

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Key information

Conditions

Cirrhosis Fibrosis Infections Inflammation Pathologic Processes Pathological Conditions, Signs and Symptoms Sepsis Systemic Inflammatory Response Syndrome

Sex eligibility

All sexes

Study type

Observational

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Clinically or pathologically diagnosed with cirrhosis;
  • meets the Sepsis-3 diagnostic criteria.

Exclusion criteria

  • Combined organ transplantation, active malignant tumors;
  • Pregnant or breastfeeding women;
  • Long-term use of immunosuppressants (non-steroidal);
  • Death or voluntary discharge within 24 hours of admission;
  • Incomplete data.

Treatment and study plan

Primary outcomes

  1. 28-day all-cause mortality in cirrhosis with sepsis

    Time frame: Baseline and 28 days.

Interested in participating?

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Trial opening soon.

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Sponsors and collaborators

Lead sponsor

The Second Affiliated Hospital of Chongqing Medical University

Other

Registry information

Official study title

Use of Antimicrobial Drugs in Severe Infections and Epidemiological Study of Populations With Severe Infections

Important dates

Study start
2026
Primary completion
2027
Study completion
2028
First posted
Mar 11, 2026
Registry last updated
Mar 11, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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