Prevalence of Treponema Parvum in Subgingival Microbiome of Patients With Periodontitis

The current study primarily aims to evaluate the presence of T. parvum in periodontal health and disease, and its correlation with clinical parameters. Subgingival plaque samples will be collected using sterile paper points then the samples will be analyzed using quantitative polymerase chain reaction (qPCR) to detect T. parvum and estimate its relative amount in the biofilm. The results may help clarify the association between T. parvum and periodontitis.

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Key information

Conditions

Periodontitis Mouth Diseases Periodontal Diseases Stomatognathic Diseases

Age range

30 year and older

Sex eligibility

All sexes

Study type

Observational

Primary location

College of Dentistry, University of Baghdad

Baghdad, 10047, Iraq

Location status: Recruiting

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

include participants who have at least 20 teeth and diagnosed as generalized periodontitis.

Exclusion criteria

participants meeting any of the following criteria were excluded: (1) undergoing orthodontic treatment; (2) having a history of antibiotic/nonsteroidal anti-inflammatory drugs use within the last three months; (3) having a history of valve replacement who need prophylactic antibiotic coverage; (4) pregnant or lactating women; (5) having a history periodontal therapy within the last six month.

Treatment and study plan

Primary outcomes

Relative abundance of T. parvum in subgingival biofilm

Time frame: At enrollment

Detection and relative abundance of T. parvum in subgingival biofilm measured by qPCR from subgingival plaque collected using sterile paper points

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Sponsors and collaborators

Lead sponsor

University of Baghdad

Other

Registry information

Official study title

Prevalence of Treponema Parvum in Subgingival Microbiome of Patients With Periodontitis: A Case-Control Study

Important dates

Study start: 2025
Primary completion: 2026
Study completion: 2026
First posted: Mar 2, 2026
Registry last updated: Mar 2, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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