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Completed

NCT Number: NCT07367347

Effect of Increased BMI on Efficacy of Labor Analgesia

This study seeks to identify the most effective neuraxial technique for labor analgesia in Class III parturient

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Key information

Conditions

Neuraxial Analgesia Body Weight Labor Analgesia Nutrition Disorders Nutritional and Metabolic Diseases Obesity Overnutrition Overweight Pathological Conditions, Signs and Symptoms Signs and Symptoms

Age range

18 year and older

Sex eligibility

Female

Study type

Observational

Primary location

Women's Wellness and Research Center

Doha, Qatar

About this study

This retrospective cohort study collected data on eligible participants from the electronic medical records.

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Age > or equal to 18 years
  • BMI ≥ 40 kg/m²
  • Gestational age ≥ 28 weeks

Exclusion criteria

  • Age < 18 years
  • BMI < 40 kg/m²
  • History of venous thromboembolism or arterial disease (e.g., DVT, PE, angina, MI, or stroke)
  • Severe active lung, cardiovascular, renal, or liver disorders; autoimmune disease; or hemoglobinopathies
  • Hereditary or acquired thrombophilia (e.g., Factor V Leiden mutation or antithrombin deficiency)
  • In utero fetal demise (IUFD)
  • Failed operative vaginal delivery
  • Cesarean for the second twin or multiple pregnancies (triplets or higher)
  • IVF pregnancy
  • Intraoperative bleeding>1500mL
  • Emergency cesarean section (Category I)
  • Presence of large uterine fibroid ≥10 cm.

Treatment and study plan

Neuraxial Analgesia

Procedure

Combined spinal-epidural analgesia

Primary outcomes

  1. Success rate of labor analgesia

    Time frame: onset of neuraxial analgesia to completion of labor

    The success rate of each technique will be determined by:

    Number of patients requiring a physician top-up bolus Block symmetry First-attempt success rate

Secondary outcomes

  1. Maternal adverse events

    Time frame: onset of neuraxial analgesia to completion of labor

    Incidence of maternal hypotension, maternal bradycardia, high block (above T1), higher than T4 block, need of vasopressors, mortality, post-Dural puncture headache

  2. Fetal adverse events

    Time frame: at 1 and 5 minutes after birth

    APGAR SCORE

Sponsors and collaborators

Lead sponsor

Mariah Arif

Other Gov

Registry information

Official study title

The Effect of Increased BMI on Efficacy of Labor Analgesia: A Retrospective Cohort Study

Important dates

Study start
2025
Primary completion
2025
Study completion
2026
First posted
Jan 26, 2026
Registry last updated
Jan 27, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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