CT-Angiography Versus Angiogram as Ancillary Tests in the Determination of Death by Neurologic Criteria

Diagnostic performance of a novel protocol for computed tomography-angiography, as ancillary test in the determination of complete cerebral infarction, in comparison to four vessel angiography.

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Key information

Conditions

Infarction, Brain Brain Death Brain Diseases Brain Infarction Brain Ischemia Cardiovascular Diseases Central Nervous System Diseases Cerebral Infarction Cerebrovascular Disorders Coma Consciousness Disorders Death Infarction Ischemia Necrosis Nervous System Diseases Neurobehavioral Manifestations Neurologic Manifestations Pathologic Processes Pathological Conditions, Signs and Symptoms Stroke Unconsciousness Vascular Diseases

Age range

18 year and older

Sex eligibility

All sexes

Study type

Observational

Primary location

Karolinska University Hospital

Stockholm, 17176, Sweden

Location status: Recruiting

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

Adults 18 years or older
Ongoing critical care due to severe acute brain injury
Four vessel angiography necessary for the determination of complete cerebral infarction, according to Swedish legislation

Exclusion criteria

Treatment with extracorporeal membrane oxygenation (ECMO)
Radiologic examination by computed tomography deemed too challenging due to respiratory or circulatory instability, as determined by responsible clinician

Treatment and study plan

Primary outcomes

Diagnostic performance similar between computed tomography-angiography and four vessel angiography

Time frame: Periprocedural

Sensitivity, specificity, positive predictive value, negative predictive value, inter- and intrarater variability.

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Recruiting

Interested in participating?

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Sponsors and collaborators

Lead sponsor

Region Stockholm

Other Gov

Collaborators

Karolinska Institutet

Registry information

Official study title

A Comparison of Computed Tomography-Angiography Versus Four-vessel Angiography in the Determination of Brain Death

Acronym: Tadaa

Important dates

Study start: 2026
Primary completion: 2028
Study completion: 2028
First posted: Jan 14, 2026
Registry last updated: Mar 17, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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Completed