Gehad Salem Mohamed Mohamed Menshawi
Istanbul, Beykoz/İstanbul, 34810, Turkey (Türkiye)
Location status: Recruiting
NCT Number: NCT07230015
This trial investigates the first combined use of motor imagery and vestibular rehabilitation in multiple sclerosis, aiming to evaluate their joint effect on balance, cognition, and quality of life.
Interested in participating?
Request Info18 year–45 year
All sexes
Interventional
Not applicable
Istanbul, Beykoz/İstanbul, 34810, Turkey (Türkiye)
Location status: Recruiting
Multiple sclerosis often causes balance disturbance, cognitive decline, and reduced quality of life. Motor imagery and vestibular rehabilitation are established methods in MS care, but their effects have only been studied separately. This randomized controlled trial introduces a combined program of motor imagery and vestibular training to explore whether their integration provides broader benefits. The study will recruit patients with relapsing-remitting MS, apply an 8-week intervention, and compare outcomes in cognition, balance, physical performance, and quality of life against conventional therapy.
Healthy volunteers accepted: No
Only the study team can determine whether someone qualifies for participation.
Inclusion criteria
Exclusion criteria
Other neurological disorder, progressive multiple sclerosis Non-MS related vestibular disorders (e.g., BPPV, Meniere's disease) that would interfere with vestibular rehab.
Severe Psychiatric Conditions (schizophrenia, bipolar, etc) Sever balance disorder Sever fatigue Medical instability eg (cardiovascular disease, respiratory, infections, severe uncontrolled diabetes, or severe visual impairments.) Sever cognitive impairment Pregnant Advance disability ( wheelchair , unable to stand ) Use of Vestibular-Suppressing Medications Non - speaker Arabic
This 8-week program, 3 sessions/week, 55- 60 min each, includes 4 steps:
Warm-up (5 min): Breathing exercises progressing from basic diaphragmatic and pursed-lip breathing (weeks 1-2), light movement with breathing (weeks 3-4), to Inspiratory Muscle Training device (weeks 5-8).
Motor Imagery (15 min): Foundational phase (weeks 1-2) imagining basic movements, skills building (weeks 3-4) with functional daily tasks, advanced phase (weeks 5-8) imagining complex tasks, environmental and cognitive challenges (e.g., sports, obstacle navigation, walking on uneven surfaces).
Vestibular Rehabilitation (15 min): Foundational (weeks 1-2) gaze stabilization and static balance (VOR, VSR, VCR), dynamic balance and dual-task exercises (weeks 3-6), advanced functional balance and vestibular-cognition integration (weeks 7-8).
Cool-down (10 min): Relaxation and symptom monitoring to prevent overexertion, dizziness, or fatigue.
This 8-week program, 3 sessions/week, 55- 60 min each, includes:
Warm-up: Seated/standing marching, neck and shoulder stretching.
Strength & Functional Movements: Sit-to-stand, side leg raises, step-ups.
Core & Upper Body: Bridge exercise, seated core activation, seated leg lifts, wall push-ups, seated shoulder press.
Flexibility & Balance: Calf and hamstring stretches, spinal flexibility, single-leg stance, lunges, tandem walking.
Cool-down: Deep breathing and gentle stretching.
Time frame: Baseline and 8 weeks after intervention
It is a cognitive screening tool commonly used in clinics and research to assess individual cognitive impairment and its severity. It helps therapists evaluate a patient's cognitive function and identify changes over time by assessing mental capacity functions and takes about 10-15 minutes to complete., which includes Attention & Concentration, Executive Functions, Memory, Language, Visuospatial Skills and Orientation (19).
Time frame: Baseline (Week 0) and Post-intervention (Week 8)
To assess balance and fall risk in Arabic-speaking patients with neurological disorders, lower scores indicate more severe balance problems (23).
Time frame: Baseline and Week 8.
DVA assesses visual acuity during head movement to evaluate vestibulo-ocular reflex integrity.It is a functional test designed to evaluate the integrity of the vestibulo-ocular reflex (VOR), which stabilizes the eyes during head motion. DVA is commonly employed to detect vestibular dysfunction and is particularly useful for evaluating vestibular function in patients experiencing dizziness, balance disorders, or conditions such as multiple sclerosis (MS), where vestibular dysfunction is common
Time frame: Baseline and Week 8
Bedside assessment of semicircular canal/VOR function. Outcome recorded as presence/absence of corrective saccades and qualitative clinician rating of gain; improvement indicates better vestibular function.It is a clinical test used to identify deficits in the semicircular canals, especially the horizontal canal, and is useful for detecting peripheral vestibular deficits. It assesses the ability of the vestibulo-ocular reflex (VOR) to maintain stable vision during rapid, unpredictable head movements
Time frame: Baseline (Week 0) and Post-intervention (Week 8)
Cognition will be assessed using BICAMS (SDMT, CVLT-II, BVMT-R). A composite and subtest scores will be calculated; This test is valdiated in Egyption dialect. It is a specialized tool designed for patients with multiple sclerosis to assess their cognitive function. It is reliable, quick, and sensitive, making it useful for both clinical settings and research. The tool focuses on cognitive domains that are commonly affected in multiple sclerosis, such as memory, speed, and learning. It includes tests like the Symbol Digit Modalities Test (SDMT), California Verbal Learning Test-II (CVLT-II), and Brief Visuospatial Memory Test-Revised (BVMT-R)
Time frame: Baseline and Week 8
Seconds to stand up, walk 3 m, turn, return, and sit. Lower times indicate better mobility; ≥12 s suggests increased fall risk.
Time frame: Baseline and Week 8.
Self-reported disability (0-8); higher scores indicate greater disability.
Time frame: Baseline and Week 8.
The Multiple Sclerosis Impact Scale-29 (MSIS-29) is a clinical tool used by patients to assess the impact of MS on their quality of life. The questionnaire consists of 29 questions and evaluates both physical and psychological well-being, helping to determine how MS affects daily life
Interested in participating?
Request InfoMedipol University
Other
The Effectiveness of Combination of Motor Imagery and Vestibular Rehabilitation on Balance, Cognition, and Quality of Life in Patients With Multiple Sclerosis
Acronym: MIVR-MS
OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.
View the official ClinicalTrials.gov record (opens in a new tab)This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.
Published trials that share one or more normalized conditions with this study.
NCT07758270
Autoimmune Diseases, Autoimmune Diseases of the Nervous System
St Louis, Missouri, United States
View Trial DetailsNCT07225361
Autoimmune Diseases, Autoimmune Diseases of the Nervous System
Chicago, Illinois, United States
View Trial DetailsNCT07376772
Autoimmune Diseases, Autoimmune Diseases of the Nervous System
Gainesville, Florida, United States
View Trial DetailsNCT07360977
Autoimmune Diseases, Autoimmune Diseases of the Nervous System
Messina, Italy
View Trial Details