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OpenTrials
Completed

NCT Number: NCT07102693

Left Atrial Strain Assessment in Ischemic Stroke Patients

This study is investigating a potential link between a novel measurement made on cardiac ultrasound and the risk of ischemic stroke in patients with a normal heart rhythm. The novel measurement is called left atrial strain. It uses speckle tracking echocardiography to measure the muscle function of the left atrium, one of the cardiac chambers. Investigators investigated whether patients with lower function of this chamber are at a higher risk of developing stroke from blood clots traveling to the brain. It is already known that patients with an irregular heart rhythm known as atrial fibrillation are at higher risk of these types of strokes. Investigators wanted to determine if there is a similar association in patients with normal heart rhythm but low left atrial strain.

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Key information

Conditions

Ischemic Stroke Brain Diseases Cardiovascular Diseases Central Nervous System Diseases Cerebrovascular Disorders Left Atrial Strain Nervous System Diseases Sinus Rhythm Stroke Vascular Diseases

Age range

18 year and older

Sex eligibility

All sexes

Study type

Observational

Primary location

Connolly Hospital Blanchardstown

Dublin, Co. Dublin, D15 X40D, Ireland

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Emergency department presentation with FAST positive symptoms
  • Neuroimaging performed as part of stroke workup
  • Echocardiogram performed during index admission

Exclusion criteria

  • Any history of atrial fibrillation prior or during admission
  • Age below 18 years of age
  • No echocardiogram or echocardiogram images not of sufficient quality to perform left atrial strain analysis
  • At least moderate mitral regurgitation
  • ASD or PFO

Treatment and study plan

Primary outcomes

  1. Correlation between left atrial strain and acute ischaemic stroke

    Time frame: 2 weeks

    This correlation will be adjusted for common stroke risk factors such as age, gender, hypertension, smoking, dyslipidaemia, and diabetes.

Sponsors and collaborators

Lead sponsor

Connolly Hospital Blanchardstown

Other

Registry information

Official study title

Left Atrial Strain Assessment in Ischemic Stroke Patients: a Retrospective Case-control Study - the ASSISTANT Study

Acronym: ASSISTANT

Important dates

Study start
2024
Primary completion
2025
Study completion
2025
First posted
Aug 5, 2025
Registry last updated
Aug 12, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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