Effects of Pulmonary Resection on Right Ventricular Function

Lung resection is associated with high postoperative morbidity and mortality and leads to a significant long-term decrease in functional capacity, particularly due to cardiorespiratory complications. One of the contributing factors to this functional decline is the postoperative reduction in right ventricular function. Due to the anatomical proximity and interactions, right ventricular function is evaluated by echocardiography following lung resection. The pulmonary artery pressure (PAP)/tricuspid annular plane systolic excursion (TAPSE) ratio is a parameter that provides a more comprehensive assessment of right heart function by evaluating both right ventricular systolic function and pulmonary artery pressure. In this study, investigators aimed to evaluate changes in right heart function by performing preoperative and postoperative echocardiographic assessments in participants undergoing lung resection, focusing on PAP/TAPSE ratios.

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Key information

Conditions

Pulmonary Resection Cardiothoracic Anesthesia Echocardiography Right Ventricular Function

Age range

18 year–80 year

Sex eligibility

All sexes

Study type

Observational

Primary location

Gazi University Faculty of Medicine, Ankara

Ankara, Yenimahalle, 06500, Turkey (Türkiye)

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

Adults aged 18 to 80 years

ASA classification I-III

Patients scheduled to undergo lung resection in thoracic surgery

Exclusion criteria

Patients with arrhythmia

Patients using antiarrhythmic drugs

Patients with renal failure requiring hemodialysis

Patients with a history of previous lung surgery

Patients with valvular heart disease

Patients with a history of angina pectoris or myocardial infarction within the past month

Patients with FEV1/FVC ratio below 60%

Treatment and study plan

Primary outcomes

Echocardiographic Assessment: TAPSE/PASP Ratio

Time frame: Preoperatively, on postoperative days 2-4, and at postoperative month 2

Patients will undergo transthoracic echocardiographic evaluation preoperatively, on postoperative days 2-4, and at postoperative month 2. The TAPSE/PASP ratio will be calculated and recorded in mm/mmHg as a non-invasive surrogate of right ventricular-pulmonary arterial coupling.
Echocardiographic Assessment: Tricuspid Annular Plane Systolic Excursion (TAPSE)

Time frame: Preoperatively, on postoperative days 2-4, and at postoperative month 2

Patients will undergo transthoracic echocardiographic evaluation preoperatively, on postoperative days 2-4, and at postoperative month 2. TAPSE will be measured and recorded in millimeters (mm).

Other outcomes

Echocardiographic Assessment: Pulmonary Artery Systolic Pressure (PASP)

Time frame: Preoperatively, on postoperative days 2-4, and at postoperative month 2

Patients will undergo transthoracic echocardiographic evaluation preoperatively, on postoperative days 2-4, and at postoperative month 2. PASP will be estimated by transthoracic echocardiography and recorded in millimeters of mercury (mmHg).

Sponsors and collaborators

Lead sponsor

Çağrı Özdemir

Other

Registry information

Official study title

Echocardiographic Assessment of Right Ventricular Function After Pulmonary Resection

Important dates

Study start: 2025
Primary completion: 2026
Study completion: 2026
First posted: Jun 29, 2025
Registry last updated: Aug 20, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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Completed