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NCT Number: NCT07035743

Bronchial Response to Exercise After Double Lung Transplantation

This study aims to investigate the airway response to exercise and its association with breathlessness in double lung transplant recipients by comparing responses during 5-minute and 15-minute exercise durations.

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Key information

Conditions

Airway Response Challenge Test Dyspnea Lung Transplant Lung Transplant Recipients Pathological Conditions, Signs and Symptoms Respiration Disorders Respiratory Tract Diseases Signs and Symptoms Signs and Symptoms, Respiratory

Age range

20 year and older

Sex eligibility

All sexes

Study type

Observational

Primary location

Chang Gung Memorial Hospital, Linkou Branch

Taoyuan, 33305, Taiwan

Location status: Recruiting

About this study

Participants will undergo a constant workload challenge set at 60% of their peak oxygen uptake in 2 separate sessions: a 5-minute and a 15-minute exercise session, conducted in a random order. Ratings of perceived exertion will be measured every 5 minutes during exercise. Forced expiratory volume in 1 second will be performed before exercise, immediately post-exercise, and at 5, 10, 15, 20, and 30 minutes post-exercise in order to assess the airway response.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Received double lung transplantation
  • ≥ 3 months post-transplant

Exclusion criteria

  • Diagnosis of asthma
  • Significant airflow limitation (≤50% FEV1 predicted)
  • Inability to cooperate with the required tests and measurements
  • Recent infection or rejection within 1 month
  • Exercise contraindication (e.g., recent heart attack or stroke within 3 months, uncontrolled hypertension, known aortic aneurysm, unstable cardiac ischemia, malignant arrhythmias)

Treatment and study plan

Exercise

Other

5 minutes of constant workload exercise at 60% of peak oxygen uptake from cardiopulmonary exercise testing

Other names: 5-minute exercise

Primary outcomes

  1. Percentage change in FEV1 from baseline

    Time frame: from enrollment to up to 12 weeks

    Percentage change in FEV1 from baseline at immediately post-exercise, 5, 10, 15, 20, and 30 minutes post-exercise.

Interested in participating?

Recruiting

Interested in participating?

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Sponsors and collaborators

Lead sponsor

Chang Gung Memorial Hospital

Other

Collaborators

  • National Taiwan University

Registry information

Important dates

Study start
2025
Primary completion
2025
Study completion
2025
First posted
Jun 25, 2025
Registry last updated
Jun 25, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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