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OpenTrials
Completed

NCT Number: NCT07033533

Allopurinol and Pathogenesis of Cirrhosis

Hepatic decompensation is a common healthcare issue

. This study was conducted to investigate how allopurinol can interfere with the pathological mechanisms of HD.

Completed

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Key information

Conditions

Cirrhoses, Liver

Age range

18 year–75 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Phase 1 / Phase 2

Primary location

Tanta University

Tanta, Egypt

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • age 18-75 both sex

Exclusion criteria

  • active GIT bleeding

Treatment and study plan

Allopurinol Tablet

Drug

allopurinol 300

Placebo

Drug

placebo tablet

Primary outcomes

  1. Levels of gut barrier and microbial translocation biomarkers, including zonulin, lipopolysaccharide (LPS), and malondialdehyde (MDA), measured in serum/plasma.

    Time frame: 6 MONTHS

    Levels of gut barrier and microbial translocation biomarkers, including zonulin, lipopolysaccharide (LPS), and malondialdehyde (MDA), measured in serum/plasma.

Sponsors and collaborators

Lead sponsor

Tanta University

Other

Registry information

Official study title

Allopurinol Interferes With the Pathological Mechanisms of Hepatic Decompensation

Important dates

Study start
2023
Primary completion
2024
Study completion
2024
First posted
Jun 24, 2025
Registry last updated
Sep 11, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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