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NCT Number: NCT07000786

EUmetriosis: Insights Into the Pathogenesis of Endometriosis

This study investigates epigenetic changes in menstrual effluent and plasma from women with endometriosis to identify potential non-invasive diagnostic biomarkers for the disease.

Recruiting

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Key information

Conditions

Endometriosis Female Urogenital Diseases Female Urogenital Diseases and Pregnancy Complications Genital Diseases Genital Diseases, Female Urogenital Diseases

Age range

18 year–56 year

Sex eligibility

Female

Study type

Interventional

Phase

Not applicable

Primary location

Cliniques universitaires Saint-Luc

Brussels, 1200, Belgium

Location status: Recruiting

Location contact

Marie-Madeleine Dolmans, MD, PhD

CONTACT

[email protected]

+32 (0)2 764 5287

Marie-Madeleine Dolmans, MD, PhD

PRINCIPAL_INVESTIGATOR

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Premenopausal
  • In spontaneous menstrual cycle (no hormonal treatments for the last 3 months)
  • Healthy or with a clear diagnosis of endometriosis via ultrasound, MRI or laparoscopy

Exclusion criteria

  • HIV or Hepatitis positive
  • Pregnancy

Treatment and study plan

Endometrial biopsy or menstrual cup and blood sample

Procedure

Enrolled patients will give their menstrual effluent either via a menstrual cup or via a pipelle biopsy. They will also undergo a blood draw.

Primary outcomes

  1. Epigenetic analysis

    Time frame: Throughout the entire study, approximately during 3,5 years

    Histone post-translational modifications

  2. Epigenetic analysis

    Time frame: Throughout the entire study, approximately during 3,5 years

    miRNA

Study contacts

Contact information is provided by the study sponsor or research team.

Marie-Madeleine Dolmans, MD, PhD

CONTACT

[email protected]

+32 (0)2 764 5287

Sponsors and collaborators

Lead sponsor

Université Catholique de Louvain

Other

Registry information

Acronym: EUmetriosis

Important dates

Study start
2025
Primary completion
2029
Study completion
2029
First posted
Jun 3, 2025
Registry last updated
Jun 3, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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