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NCT Number: NCT06948162

Exploration of the Utility of Dental-dedicated MRI for Dentistry

This description observational research is comparative in design, that is comparing existing standard clinical dental images, not obtained in this study, to test (i.e., ddMRI) images. The standard clinical dental images consist of radiographs, such as bitewings, periapical, panoramic, cone-beam CT, and medical CT, as well medical MRIs of the temporomandibular joints (TMJ).The conceptualization of research questions, study designing, and interpretation of imaging data has and will involve content expertise in all ddMRI research.

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Key information

Conditions

Dental Crowding Behavior Crowding Dental Occlusion, Traumatic Dental Pulp Diseases Disease Endodontic Disease Endodontic Histopathology Endodontic Lesions Facial Pain Local Anesthesia Malocclusion Mouth Diseases Nervous System Diseases Neurologic Manifestations Oral Surgery Conditions Orthodontic Treatment Orthodontics Pain Pathologic Processes Pathological Conditions, Signs and Symptoms Periodontal Diseases PeriodontalConditions Periodontitis Signs and Symptoms Spatial Behavior Stomatognathic Diseases TMJ Tooth Diseases Tooth Extractions Traumatic Dental Pain

Age range

18 year and older

Sex eligibility

All sexes

Study type

Observational

Primary location

Orofacial MRI Center(OMRIC), University of Minnesota, School of Dentistry, Malcolm Moos Health Sciences Tower, 515 Delaware St. SE,

Minneapolis, Minnesota, 55455, United States

Location status: Recruiting

Location contact

Kristin Artinger, PhD

PRINCIPAL_INVESTIGATOR

Rania Nuwailati, BDS, MS, PhD

CONTACT

[email protected]

612-626-8431

Sara Duffy, BS

CONTACT

[email protected]

612-626-1025

About this study

Patients of record will be recruited from dental clinics at the University of Minnesota School of Dentistry will be screened for eligibility and asked to complete an MRI safety screening questionnaire. Eligible individuals will be invited to participate in at least one study visit, during which an MRI scan will be performed.

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Patient Age: 18 years old or older
  • Receiving imaging for routine dental care
  • Does not have a serious medical condition
  • Is not pregnant or is not potentially pregnant
  • Is willing and able to give consent in English
  • Has the ability to manage their own calendar and schedule appointments
  • Willing to have a separate 2-hour appointment to have an MRI

Exclusion criteria

  • Unable to consent to participant in English
  • Serious health condition, which includes but not limited to renal failure/on dialysis, unstable heart disease (uncontrolled arrhythmia, cardiomyopathy and/or unable to lay flat, within 1 month of cardiac catheterization or myocardial infarction), unstable cerebral vascular disease (within 1 month of stroke and/or stent placement), diabetes (type I or II) not controlled by medication or diet, uncontrolled seizures, uncontrolled hyperthyroidism, non-allergic bronchospasm (chronic obstructive pulmonary disease and emphysema), uncontrolled movement disorder, and liver failure
  • Pregnant and/or intending to become pregnant,
  • Prisoner and/or not able to manage their own scheduling
  • Screen positive on MR safety questionnaire, specifically including people that have worked with or otherwise been exposed to metal particles and have the potential for such particles to be embedded within them.

Treatment and study plan

dental-dedicated MRI (ddMRI)

Device

This descriptive observational research is comparative in design, that is comparing existing standard clinical dental images, not obtained in this study, to test (i.e., ddMRI) images.

Primary outcomes

  1. Feasibility and Safety Assessment of ddMRI in Dental Patients

    Time frame: 1 year

    Evaluate the feasibility and safety of dental-dedicated MRI (ddMRI) in dental patients by assessing their experiences immediately following each scan. This will be done using an exit questionnaire designed to capture any sensations or discomfort that may have occurred during the scan. Participants will be asked to report the presence of various sensations, including but not limited to: nervousness, double vision, sleepiness, vertigo, lightheadedness, metallic taste, and feelings of warmth or cold. The collected responses will help determine the overall tolerability of ddMRI in this patient population.

  2. Diagnostic Quality Assessment of ddMRI in Dental Patients

    Time frame: 1 year

    The diagnostic quality of dental-dedicated MRI (ddMRI) in dental patients will be evaluated through subjective ratings of its ability to identify various dentoalveolar anatomical structures. These ratings will be compared to those obtained from existing standard dental imaging modalities. Additionally, intra- and inter-rater reliability analyses will be conducted to assess the consistency of the ddMRI interpretations and their agreement with conventional dental imaging.

  3. Anatomical landmark identification and inflammation detection

    Time frame: 3 years

    Compare the diagnostic efficacy of ddMRI versus existing clinical imaging (e.g., plain film, CT, MRI) in terms of identifying anatomical landmarks and detecting the presence of inflammation, as rated by dental specialist examiners.

Study contacts

Contact information is provided by the study sponsor or research team.

Kelli Trauger, MS, DH, RF

CONTACT

[email protected]

612-624-2231

Sara Duffy, BS,

CONTACT

[email protected]

612-626-1025

Sponsors and collaborators

Lead sponsor

University of Minnesota

Other

Collaborators

  • American Association for Endodontics Foundation
  • Dentsply North America LLC
  • Siemens Medical Solutions USA Inc. (Siemens Healthineers)

Registry information

Important dates

Study start
2025
Primary completion
2027
Study completion
2028
First posted
Apr 29, 2025
Registry last updated
Aug 25, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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