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NCT Number: NCT06898944

Prognosis and Risk Factors for Acute Kidney Injury

The aim of our study is to analyze the accurate diagnosis and prognosis of acute kidney injury (AKI) based on its severity and to define long-term clinical and socioeconomic outcomes.

Investigators defined the AKI group among adults aged 20 years or older who visited enrolled center and underwent at least two blood tests, including serum creatinine, within an interval of 7 days or less and a control group was matched 1:1 to the AKI group based on age, sex, year of visit, and baseline kidney function, forming the study population. Investigators then collected and analyzed various clinical, laboratory, and hospitalization records including demographic data, anthropometric data, laboratory data, and medical history.

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Key information

Conditions

Acute Kidney Injury Female Urogenital Diseases Female Urogenital Diseases and Pregnancy Complications Kidney Diseases Male Urogenital Diseases Renal Insufficiency Urogenital Diseases Urologic Diseases

Age range

20 year and older

Sex eligibility

All sexes

Study type

Observational

Primary location

Seoul National University Hospital

Seoul, 03080, South Korea

Location status: Recruiting

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Adults over 20 years old who visited Parcitipating Medical Center (Seoul National University Hospital, Bundang Seoul National University Hospital, SMG-SNU Boramae Medical Center, Keimyung University Dongsan Medical Center) between 2006 and 2021
  • The AKI group is defined as individuals meeting the AKI diagnostic criteria of the KDIGO Guideline (an increase in serum creatinine of ≥0.3 mg/dL or ≥1.5 times the baseline level) is enrolled.
  • The Control Group is defined as individuals from the study population who do not meet the AKI criteria and are matched 1:1 based on age, sex, year of visit, and baseline renal function.

Exclusion criteria

  • Individuals under 20 years old
  • Individuals who did not undergo serum creatinine tests meeting the criteria
  • Individuals with pre-existing end-stage kidney disease (ESKD) who have undergone dialysis or kidney transplantation

Treatment and study plan

Primary outcomes

  1. Change from Baseline in Serum Creatinine

    Time frame: From Index Date(The Date Which Acute Kidney Injury Occured) Through 5 Years After The Index Date

Secondary outcomes

  1. Change from Baseline in Urine Protein/Creatinine Ratio

    Time frame: From Index Date(The Date Which Acute Kidney Injury Occured) Through 5 Years After The Index Date

  2. Incidence of Receiving Renal Replacement Therapy

    Time frame: From Index Date(The Date Which Acute Kidney Injury Occured) Through 5 Years After The Index Date

  3. Change from Baseline in Serum Hemogloblin Level

    Time frame: From Index Date(The Date Which Acute Kidney Injury Occured) Through 5 Years After The Index Date

  4. Change from Baseline in Serum Albumin Level

    Time frame: From Index Date(The Date Which Acute Kidney Injury Occured) Through 5 Years After The Index Date

Interested in participating?

Recruiting

Interested in participating?

Request Info

Sponsors and collaborators

Lead sponsor

Seoul National University Hospital

Other

Collaborators

  • Keimyung University Dongsan Medical Center
  • SMG-SNU Boramae Medical Center
  • Seoul National University Bundang Hospital

Registry information

Official study title

Analysis for Prognosis and Risk Factors for Acute Kidney Injury: Multi-center Cohort Study

Important dates

Study start
2022
Primary completion
2026
Study completion
2026
First posted
Mar 27, 2025
Registry last updated
Apr 2, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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