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Recruiting

NCT Number: NCT06835816

Amino Acid Supplementation in Continuous Renal Replacement Therapy

ICU patients treated with continuous renal replacement therapy is recruited prior to start of treatment.

Blood samples are drawn and then dialysis start without amino acid supplementation. After a few hours samples are drawn from blood and dialysate. Then patients are given amino acid supplementation (33.5g/24hrs) for 20-24 hours. New samples are drawn and amino acid supplementation is increased to 67g/24hrs and new samples are drawn after additional 24 hours. Then CRRT will continue with the full amino acid supplementation (standars of care).

Recruiting

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Key information

Conditions

Acute Kidney Injury Female Urogenital Diseases Female Urogenital Diseases and Pregnancy Complications Kidney Diseases Male Urogenital Diseases Renal Insufficiency Urogenital Diseases Urologic Diseases

Age range

18 year and older

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Karolinska University Hospital

Stockholm, 14186, Sweden

Location status: Recruiting

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Dialysis where amino acid supplementation is planned by treating physician

Exclusion criteria

  • Liver failure
  • Muscle disease
  • Neurodegenerative disease

Treatment and study plan

Amino acid supplementation (Glavamin, Fresenius Kabi)

Dietary Supplement

Mixture of amino acids (67 g / 500 ml) given intravenously

Primary outcomes

  1. Balance of amino acids

    Time frame: After 3 days of dialysis

    Total balance of amino acid losses and supplementation given

Secondary outcomes

  1. Amino acid concentration in plasma

    Time frame: After 3 days of dialysis

    Concentration of various amino acids in plasma without and with supplementation

  2. Concentration of vitamins and trace elements

    Time frame: After 3 days of dialysis

    Analysis of various trace elements and vitamins

Interested in participating?

Recruiting

Interested in participating?

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Sponsors and collaborators

Lead sponsor

Karolinska University Hospital

Other

Registry information

Acronym: AARRT

Important dates

Study start
2025
Primary completion
2026
Study completion
2028
First posted
Feb 19, 2025
Registry last updated
Feb 19, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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