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Completed

NCT Number: NCT06832826

Colonic Polypectomy in Cirrhotic Patients With Portal Hypertension

The goal of this retrospective cohort study is to evaluate the risk of post-polypectomy bleeding following the colonoscopy resection of lower gastrointestinal polyps in patients with liver cirrhosis with portal hypertension. The main question it aims to answer is:

Does the risk of bleeding increase after colonoscopy polypectomy in patients with liver cirrhosis with portal hypertension?

Participants will be subjected to polypectomy of any colonic polyps.

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Key information

Conditions

Liver Cirrhosis Colonic Polyps Digestive System Diseases Fibrosis Hypertension, Portal Intestinal Polyps Liver Diseases Pathologic Processes Pathological Conditions, Anatomical Pathological Conditions, Signs and Symptoms Polyp of Colon Polypectomy Polyps Portal Hypertension Related to Cirrhosis

Age range

18 year and older

Sex eligibility

All sexes

Study type

Observational

Primary location

Zagazig University Hospital

Zagazig, Sharqia Province, 44519, Egypt

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • All liver cirrhosis patients with portal hypertension and colonic polyps

Exclusion criteria

  • Patients with platelet count less than 50,000/µL.
  • Patients with hemoglobin levels less than 8 g/dL.
  • Prothrombin Time more than 20 seconds.

Treatment and study plan

Primary outcomes

  1. Immediate post polypectomy bleeding (IPPB)

    Time frame: During procedure

  2. Delayed post polypectomy bleeding (DPPB)

    Time frame: 24 hours to 14 days

Secondary outcomes

  1. Type of polyps in patients with liver cirrhosis and portal hypertension

    Time frame: 14 days

    Using the Paris classification system for polyps

Other outcomes

  1. Prediction of risk of post polypectomy bleeding

    Time frame: 6 months

    Using the updated Endoscopic Resection Group of the Spanish Society of Endoscopy model and the Australian Colonic Endoscopic Resection model

Sponsors and collaborators

Lead sponsor

Zagazig University

Other Gov

Registry information

Official study title

Challenges in Colonic Polypectomy and Endoscopic Mucosal Resection in Cirrhotic Patients With Portal Hypertension: Single-Center Experience

Important dates

Study start
2024
Primary completion
2024
Study completion
2025
First posted
Feb 18, 2025
Registry last updated
Sep 4, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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